N-[苄氧羰基]-L-天冬氨酸 4-叔丁酯 1-甲酯合成路线 （共 14 条）
反应条件
Alcalase-cross-linked-enzyme-aggregates in tert-butyl alcohol T=37°C; pH=7.5; 16 h; aq. phosphate bufferEnzymatic reaction; regioselective reaction;
参考文献
Nuijens, Timo; Kruijtzer, John A.W.; Cusan, Claudia; Rijkers, Dirk T.S.; Liskamp, Rob M.J.; Quaedflieg, Peter J.L.M.
Tetrahedron Letters, 2009 , vol. 50, # 23 p. 2719 - 2721
反应条件
trifluoroacetic acid in dichloromethane Ambient temperature;
参考文献
Misiti; Santaniello; Zappia
Synthetic Communications, 1992 , vol. 22, # 6 p. 883 - 891
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol; water 0.666667 h;
参考文献
LG Chem Investment Ltd.
Patent: US6747050 B1, 2004 ;
Location in patent: Page/Page column 45 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 2 - 3 h;
参考文献
LG LIFE SCIENCES LTD.
Patent: WO2008/16239 A1, 2008 ;
Location in patent: Page/Page column 75-76 ;
WO 2008/016239 A1
参考文献
LG Chem Investment Ltd.
Patent: US6747050 B1, 2004 ;
Location in patent: Page/Page column 44-45 ;
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine; di-tert-butyl dicarbonate in acetonitrile
T=20°C; 24 h;
参考文献
Nuijens, Timo; Kruijtzer, John A.W.; Cusan, Claudia; Rijkers, Dirk T.S.; Liskamp, Rob M.J.; Quaedflieg, Peter J.L.M.
Tetrahedron Letters, 2009 , vol. 50, # 23 p. 2719 - 2721
反应条件
in methanol; toluene
T=20°C; 0.25 h;
参考文献
Heredia-Moya, Jorge; Kirk, Kenneth L.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 11 p. 5908 - 5913
反应条件
sulfuric acid in dichloromethane
参考文献
Scoffone,E. et al.
Gazzetta Chimica Italiana, 1964 , vol. 94, p. 695 - 709
反应条件
1: N-methyl morpholine / ethyl acetate / 0.25 h
2: ethyl acetate; diethyl ether / 4 h / 0 °C
3: silver benzoate, Et3N / methanol
View Scheme
参考文献
Misiti; Santaniello; Zappia
Synthetic Communications, 1992 , vol. 22, # 6 p. 883 - 891
反应条件
1: ethyl acetate; diethyl ether / 4 h / 0 °C
2: silver benzoate, Et3N / methanol
View Scheme
参考文献
Misiti; Santaniello; Zappia
Synthetic Communications, 1992 , vol. 22, # 6 p. 883 - 891
