2-(4-甲氧基苯基)哌啶合成路线 （共 15 条）
反应条件
2,3,4,5,6-pentafluorostyrene; hydrogen; Piers’ borane in toluene
T=120°C; P=56255.6 Torr; 38 h; GloveboxAutoclave; stereoselective reaction;
参考文献
Liu, Yongbing; Du, Haifeng
Journal of the American Chemical Society, 2013 , vol. 135, # 35 p. 12968 - 12971
反应条件
2,3,4,5,6-pentafluorostyrene; hydrogen; Piers’ borane in toluene
T=100°C; P=37503.8 Torr; 20 h; GloveboxAutoclave; stereoselective reaction;
参考文献
Liu, Yongbing; Du, Haifeng
Journal of the American Chemical Society, 2013 , vol. 135, # 35 p. 12968 - 12971
反应条件
aluminium trichloride in acetonitrile
T=0 - 20°C; 0.25 h;
参考文献
Le Gall, Erwan; Gosmini, Corinne; Troupel, Michel
Tetrahedron Letters, 2006 , vol. 47, # 4 p. 455 - 458
反应条件
1: 96 percent / acetic acid / 1.5 h / 80 °C
2: 38 percent / pinacolone / Ru3(CO)12 / 12 h / 150 °C
3: 97 percent / hydrazine; acetic acid / ethanol / 1 h / 120 °C
View Scheme
参考文献
Pastine, Stefan J.; Gribkov, Denis V.; Sames, Dalibor
Journal of the American Chemical Society, 2006 , vol. 128, # 44 p. 14220 - 14221
反应条件
1: 38 percent / pinacolone / Ru3(CO)12 / 12 h / 150 °C
2: 97 percent / hydrazine; acetic acid / ethanol / 1 h / 120 °C
View Scheme
参考文献
Pastine, Stefan J.; Gribkov, Denis V.; Sames, Dalibor
Journal of the American Chemical Society, 2006 , vol. 128, # 44 p. 14220 - 14221
反应条件
sodium tetrahydroborate in ethanol
参考文献
Boivin, Jean; Pothier, Julien; Zard, Samir Z.
Tetrahedron Letters, 1999 , vol. 40, # 19 p. 3701 - 3704
反应条件
1.1: 90 percent / n-BuLi / CH2Cl2 / -78 - 20 °C
2.1: Mg; I2 / tetrahydrofuran / 1 h / Heating
2.2: 43 percent / tetrahydrofuran / -70 - 20 °C
3.1: TFA / 2 h / 18 - 22 °C
4.1: 58 mg / NaBH4 / H2O; methanol / 18 - 22 °C
View Scheme
参考文献
Williams, Glynn D.; Pike, Richard A.; Wade, Charles E.; Wills, Martin
Organic Letters, 2003 , vol. 5, # 22 p. 4227 - 4230
反应条件
1.1: Mg; I2 / tetrahydrofuran / 1 h / Heating
1.2: 43 percent / tetrahydrofuran / -70 - 20 °C
2.1: TFA / 2 h / 18 - 22 °C
3.1: 58 mg / NaBH4 / H2O; methanol / 18 - 22 °C
View Scheme
参考文献
Williams, Glynn D.; Pike, Richard A.; Wade, Charles E.; Wills, Martin
Organic Letters, 2003 , vol. 5, # 22 p. 4227 - 4230
反应条件
1: TFA / 2 h / 18 - 22 °C
2: 58 mg / NaBH4 / H2O; methanol / 18 - 22 °C
View Scheme
参考文献
Williams, Glynn D.; Pike, Richard A.; Wade, Charles E.; Wills, Martin
Organic Letters, 2003 , vol. 5, # 22 p. 4227 - 4230
反应条件
1: 79 percent / Electrochemical reaction
2: 75 percent / AlCl3 / acetonitrile / 0.25 h / 0 - 20 °C
View Scheme
参考文献
Le Gall, Erwan; Gosmini, Corinne; Troupel, Michel
Tetrahedron Letters, 2006 , vol. 47, # 4 p. 455 - 458
