2,2-二甲基-5-苯基-1,3-二氧杂烷-4-酮合成路线 （共 20 条）
反应条件
1.1: n-BuLi; iPr2NH / hexane; tetrahydrofuran / 0.5 h / -78 °C 1.2: 65 percent / hexane; tetrahydrofuran / 4 h / -78 - 20 °C 2.1: 100 percent / KOH / ethanol / 3 h / 20 °C 3.1: 93 percent / pivalaldehyde; O2 / Co(III)-Me2opba / acetonitrile / 20 °C View Scheme
参考文献
Aitken, R. Alan; Thomas, Andrew W.
Synlett, 1998 , # 1 p. 102 - 104
反应条件
1.1: n-BuLi; iPr2NH / hexane; tetrahydrofuran / 0.5 h / -78 °C 1.2: 76 percent / HMPA / hexane; tetrahydrofuran / 4 h / -78 - 20 °C 2.1: 100 percent / KOH / ethanol / 6 h / 20 °C View Scheme
参考文献
Blay, Gonzalo; Fernandez, Isabel; Monje, Belen; Pedro, Jose R.
Molecules, 2004 , vol. 9, # 5 p. 365 - 372
反应条件
1: 51 percent / LDA 2: 92 percent / H2 3: 75 percent / 600 °C / 0.01 Torr View Scheme
参考文献
Aitken, R. Alan; Thomas, Andrew W.
Synlett, 1998 , # 1 p. 102 - 104
反应条件
sodium ethanolate Hydrolysieren des Reaktionsprodukts;
参考文献
Chem. Fabr. v. Heyden
Patent: DE729850 , 1941 ;
DRP/DRBP Org.Chem.
反应条件
1.1: n-BuLi; iPr2NH / hexane; tetrahydrofuran / 0.5 h / -78 °C 1.2: 65 percent / HMPA / hexane; tetrahydrofuran / 4 h / -78 - 20 °C 2.1: 100 percent / KOH / ethanol / 2 h / 20 °C 3.1: 95 percent / pivalaldehyde; O2 / Co(III)-Me2opba / acetonitrile / 20 °C View Scheme
参考文献
Blay, Gonzalo; Fernandez, Isabel; Monje, Belen; Pedro, Jose R.
Molecules, 2004 , vol. 9, # 5 p. 365 - 372
反应条件
1.1: n-BuLi; iPr2NH / hexane; tetrahydrofuran / 0.5 h / -78 °C 1.2: 77 percent / hexane; tetrahydrofuran / 4 h / -78 - 20 °C 2.1: 100 percent / KOH / ethanol / 9.5 h / 20 °C 3.1: 50 percent / pivalaldehyde; O2 / Co(III)-Me2opba / acetonitrile / -47 °C View Scheme
参考文献
Blay, Gonzalo; Fernandez, Isabel; Monje, Belen; Pedro, Jose R.
Molecules, 2004 , vol. 9, # 5 p. 365 - 372
反应条件
in tetrahydrofuran 48 h; Ambient temperature;
参考文献
Wanner; Schuenemann
Archiv der Pharmazie, 1987 , vol. 320, # 11 p. 1161 - 1167
反应条件
1: (+/-)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-one With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: benzyl bromide in tetrahydrofuran; hexane T=-78 - 20°C; 4 h;
参考文献
Blay, Gonzalo; Fernandez, Isabel; Monje, Belen; Pedro, Jose R.
Molecules, 2004 , vol. 9, # 5 p. 365 - 372
反应条件
lithium diisopropyl amide
参考文献
Aitken, R. Alan; Thomas, Andrew W.
Synlett, 1998 , # 1 p. 102 - 104
反应条件
1.1: n-BuLi; iPr2NH / hexane; tetrahydrofuran / 0.5 h / -78 °C 1.2: 75 percent / hexane; tetrahydrofuran / 4 h / -78 - 20 °C 2.1: 100 percent / KOH / ethanol / 3 h / 20 °C 3.1: 94 percent / pivalaldehyde; O2 / Co(III)-Me2opba / acetonitrile / 20 °C View Scheme
参考文献
Blay, Gonzalo; Fernandez, Isabel; Monje, Belen; Pedro, Jose R.
Molecules, 2004 , vol. 9, # 5 p. 365 - 372
