1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C 2: pyridine; phosphorus tribromide / dichloromethane / 1 h / 0 - 20 °C / |Inert atmosphere 3: ammonia / ethanol; water / 4 h / 20 °C View Scheme

1: pyridine; phosphorus tribromide / dichloromethane / 1 h / 0 - 20 °C / |Inert atmosphere 2: ammonia / ethanol; water / 4 h / 20 °C View Scheme

ammonia; nickel T=100°C; P=73550.8 Torr; Hydrogenation;

hydrogenchloride; zinc

1: sodium hydrogencarbonate; bromine / dichloromethane; water / 3 h / 0 - 20 °C 2: hydrogenchloride / dichloromethane; ethyl acetate / 1 h / 20 °C View Scheme

2: Zn, HCl View Scheme

1: bromination 3: Zn, HCl View Scheme

暂无反应条件数据

1.1: toluene / 3 h / Heating 2.1: 5.22 g / NaBH4 / methanol / 2 h / 20 °C 3.1: 97 percent / Et3N / CH2Cl2 / 3 h / 0 - 20 °C 4.1: 70 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 - 0 °C 5.1: 84 percent / TFA; anisole / 24 h / Heating 6.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C 6.2: 80 percent / tetrahydrofuran; hexane / 2.17 h / -78 - 20 °C 7.1: 62 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 - 20 °C 8.1: 92 percent / triethylsilyl hydride; TFA / CH2Cl2 / 2 h / 20 °C View Scheme

暂无反应条件数据