alpha-甲基-4-联苯乙酸合成路线 （共 34 条）
反应条件
1: 4-vinyl biphenyl With (C5H3N)(MeC=N(C6H4-2,6-iPr2))2; ethylmagnesium bromide; iron(II) chloride in tetrahydrofuran; diethyl ether T=20°C; 2 h; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran; diethyl ether 0.5 h; Inert atmosphere; regioselective reaction;
参考文献
Greenhalgh, Mark D.; Thomas, Stephen P.
Journal of the American Chemical Society, 2012 , vol. 134, # 29 p. 11900 - 11903
反应条件
water; methyloxirane in acetone 3 h; Irradiation;
参考文献
Sonawane, Harikisan R.; Kulkarni, Dilip G.; Ayyangar, Nagaraj R.
Tetrahedron Letters, 1990 , vol. 31, # 51 p. 7495 - 7496
反应条件
methyloxirane in water; acetone IrradiationpH neutral;
参考文献
Tetrahedron, , vol. 50, # 4 p. 1243 - 1260
反应条件
ruthenium trichloride; sodium periodate in hexane; water; ethyl acetate T=20°C; 24 h; chemoselective reaction;
参考文献
Synthesis, , # 23 art. no. F16908SS, p. 3835 - 3845
反应条件
phosphorus; iodine; acetic acid auf Siedetemperatur;
参考文献
Journal of the American Chemical Society, , vol. 65, p. 1725,1727
反应条件
1.1: Pd(PPh3)4; LiCl / tetrahydrofuran / 0.17 h / 20 °C 1.2: tetrahydrofuran / Heating 2.1: 3.37 g / aq. KOH / methanol / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 13 p. 4312 - 4331
反应条件
1.1: 51.6 g / H2SO4 / 20 °C 2.1: iPr2NEt / CH2Cl2 / 0.5 h / -15 °C 2.2: CH2Cl2 / 1 h / -15 °C 3.1: Pd(PPh3)4; LiCl / tetrahydrofuran / 0.17 h / 20 °C 3.2: tetrahydrofuran / Heating 4.1: 3.37 g / aq. KOH / methanol / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 13 p. 4312 - 4331
反应条件
1.1: iPr2NEt / CH2Cl2 / 0.5 h / -15 °C 1.2: CH2Cl2 / 1 h / -15 °C 2.1: Pd(PPh3)4; LiCl / tetrahydrofuran / 0.17 h / 20 °C 2.2: tetrahydrofuran / Heating 3.1: 3.37 g / aq. KOH / methanol / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 13 p. 4312 - 4331
反应条件
1.1: (ortho-HON=CMeC6H4PdCl)2; K2CO3 / dimethylformamide / 12 h / 120 °C 1.2: 54 percent / BuLi; HMPA / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 42 percent / (Me2N)3P=NP(NMe2)2=NEt / tetrahydrofuran / 20 °C 3.1: Mg; HgCl2 / methanol / 24 h / 20 °C 3.2: 38 percent / KOH / methanol / 24 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 67, # 15 p. 5216 - 5225
反应条件
1.1: 76 percent / methanol / 24 h / Heating 2.1: (ortho-HON=CMeC6H4PdCl)2; K2CO3 / dimethylformamide / 12 h / 120 °C 2.2: 54 percent / BuLi; HMPA / tetrahydrofuran; hexane / -78 - 20 °C 3.1: 42 percent / (Me2N)3P=NP(NMe2)2=NEt / tetrahydrofuran / 20 °C 4.1: Mg; HgCl2 / methanol / 24 h / 20 °C 4.2: 38 percent / KOH / methanol / 24 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 67, # 15 p. 5216 - 5225
