3-(2-甲氧基苯基）丙酸合成路线 （共 42 条）
反应条件
1: With borane-THF in tetrahydrofuran 4 h; 2: With methanol in tetrahydrofuran
参考文献
ABBOTT LABORATORIES
Patent: WO2008/79382 A1, 2008 ;
Location in patent: Page/Page column 127-128 ;
WO 2008/079382 A1
参考文献
Bristol-Myers Squibb Company
Patent: US5739135 A1, 1998 ;
反应条件
1: SOCl2 / benzene / Heating 2: benzene; diethyl ether 3: 10 percent / benzene / 3.5 h / Irradiation View Scheme
参考文献
Lockett; Short
Journal of the Chemical Society, 1939 , p. 787,789
参考文献
Ramart-Lucas; Hoch
Bulletin de la Societe Chimique de France, 1935 , vol. <5> 2, p. 327,333
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1935 , vol. 201, p. 1387
反应条件
1.1: oxalyl chloride / diethyl ether 2.1: 0.74 g / diethyl ether / 3 h / -20 - 20 °C 3.1: rhodium(II) acetate / CH2Cl2 / 1 h / Heating 3.2: 15 mg / TFA / CH2Cl2 / 0.17 h View Scheme
参考文献
Ghosh, Somnath; Datta, Indira; Chakraborty, Rupak; Das, Tapas Kumar; Sengupta, Judhajit; Sarkar, Dipak Chandra
Tetrahedron, 1989 , vol. 45, # 5 p. 1441 - 1446
反应条件
1: tetrachloromethane; bromine / -10 °C 2: aluminium chloride; benzene View Scheme
参考文献
Barnes; Kraft; Gordon
Journal of the American Chemical Society, 1949 , vol. 71, p. 3523,3527
参考文献
Wieringa, J.; Meerendonk, A. van den; Steenvoorden, J.; Heeres, G.; Bakel, F. van; et al.
Recueil des Travaux Chimiques des Pays-Bas, 1993 , vol. 112, # 2 p. 143 - 150
反应条件
1: 59 percent / pyridinium chloride / H2O / 0.33 h / Heating 2: 76 percent / sodium ethoxide / 1 h / 40 °C View Scheme
参考文献
Tyman, John H. P.; Grundy, Jesse; Brown, George R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 336 - 343
反应条件
1: hydrogen chloride; ethanol 2: sodium; ethanol 3: pyridine; SOCl2 4: ethanol; sodium iodide; copper (II)-sulfate 5: methanol. KOH-solution 6: POCl3; tetrachloroethane / zuletzt bei Siedetemperatur View Scheme
参考文献
Lockett; Short
Journal of the Chemical Society, 1939 , p. 787,789
反应条件
1: 94 percent / SOCl2 / benzene / 3 h / Heating 2: 98 percent / diethyl ether / Ambient temperature 3: 19 percent / <Rh(CH3COO)2>2, CF3COOH / CH2Cl2 / 0.42 h / Heating View Scheme
参考文献
Copinga, Swier; Tepper, Pieter G.; Grol, Cor J.; Horn, Alan S.; Dubocovich, Margarita L.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2891 - 2898
