4-甲脒基吡啶水合盐酸盐合成路线 （共 31 条）
反应条件
1: With sodium methylate in methanol 2 h; Reflux; 2: With ammonium chloride in methanol 2 h; Reflux;
参考文献
Bonnet, Muriel; Flanagan, Jack U.; Chan, Denise A.; Lai, Edwin W.; Nguyen, Phuong; Giaccia, Amato J.; Hay, Michael P.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 11 p. 3347 - 3356
反应条件
ammonium chloride in methanol; acetone
反应条件
1: With acetic anhydride; acetic acid T=20°C; 0.5 h; 2: With triethylsilane; palladium dichloride T=70 - 75°C; 2 h; 3: With hydrogenchloride in ethanol
参考文献
Mahajan, Umesh S.; Godinde, Rupesh R.; Mandhare
Synthetic Communications, 2011 , vol. 41, # 15 p. 2195 - 2199
反应条件
ammonium chloride in methanol 4 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 4 p. 1230 - 1241
反应条件
1: 4-pyridinecarbonitrile With sodium in methanol 0.5 h; 2: ammonium chloride 24 h;
参考文献
US6337397 B1, ;
Example 27 ;
反应条件
methanol; sodium 0.5 h;
参考文献
SANOFI-AVENTIS
Patent: US2008/125410 A1, 2008 ;
Location in patent: Page/Page column 6 ;
反应条件
1: NaOMe / methanol / 18 h / 20 °C 2: POCl3; PhNMe2 / 120 °C View Scheme
参考文献
Bolli, Martin H.; Boss, Christoph; Clozel, Martine; Fischli, Walter; Hess, Patrick; Weller, Thomas
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 5 p. 955 - 959
反应条件
1: KOEt / ethanol / Heating 2: DMF; SOCl2 / Heating View Scheme
参考文献
Tedder, Martina E.; Nie, Zhe; Margosiak, Stephen; Chu, Shaosong; Feher, Victoria A.; Almassy, Robert; Appelt, Krzysztof; Yager, Kraig M.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3165 - 3168
