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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
对氯碘苯
合成路线
(共 633 条)
637-87-6
对氯碘苯
→
反应条件
21969-11-9
4-氯-4'-硝基二苯硫醚
反应条件
1: copper(l) iodide; Na2S*9H2O; sulfur / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere 2: iron; potassium carbonate / dimethyl sulfoxide; N,N-dimethyl-formamide / 18 h / 120 °C / Inert atmosphere View Scheme
参考文献
Li, Yaming; Nie, Caiping; Wang, Huifeng; Li, Xiaoying; Verpoort, Francis; Duan, Chunying
European Journal of Organic Chemistry, 2011 , # 36 p. 7331 - 7338
637-87-6
对氯碘苯
+
150-76-5
4-甲氧基苯酚
→
反应条件
21567-18-0
4-(4-氯苯氧基)苯酚
反应条件
potassium hydroxide; hydrogen bromide; Copper(I)chloride in anhydrous xylene; acetic acid
参考文献
The United States of America as represented by the Secretary of the Air Force
Patent: US5196130 A1, 1993 ;
637-87-6
对氯碘苯
+
40138-16-7
2-甲酰基苯硼酸
→
反应条件
153850-83-0
4’-氯联苯-2-甲醛
反应条件
sodium carbonate; palladium diacetate in water; N,N-dimethyl-formamide T=20°C; Suzuki-Miyaura coupling; 24 h;
参考文献
Li, Guijie; Wang, Erjuan; Chen, Haoyi; Li, Hongfeng; Liu, Yuanhong; Wang, Peng George
Tetrahedron, 2008 , vol. 64, # 38 p. 9033 - 9043
109-72-8
正丁基锂
+
637-87-6
对氯碘苯
→
反应条件
15499-27-1
反应条件
1: n-butyllithium With indium(III) chloride in tetrahydrofuran T=-78 - 20°C; 1 h; 2: 1-chloro-4-iodobenzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; hexane Heating;
参考文献
Lee, Phil Ho; Lee, Sung Wook; Seomoon, Dong
Organic Letters, 2003 , vol. 5, # 26 p. 4963 - 4966
637-87-6
对氯碘苯
+
92273-73-9
→
反应条件
15499-27-1
反应条件
PEPPSITM-IPr; lithium bromide in tetrahydrofuran; 10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenz(b,f)azepin T=25°C; Negishi cross-coupling; 2 h; Inert atmosphere; chemoselective reaction;
参考文献
Larrosa, Igor; Somoza, Clara; Banquy, Alexandre; Goldup, Stephen M.
Organic Letters, 2011 , vol. 13, # 1 p. 146 - 149
637-87-6
对氯碘苯
+
2528-61-2
→
反应条件
15499-27-1
+
71162-44-2
反应条件
MnI2; n-butyllithium in diethyl ether Yields of byproduct given;
参考文献
Klement, Ingo; Stadtmueller, Heinz; Knochel, Paul; Cahiez, Gerard
Tetrahedron Letters, 1997 , vol. 38, # 11 p. 1927 - 1930
542-69-8
+
637-87-6
对氯碘苯
→
反应条件
15499-27-1
反应条件
CuI*P(Et)3; naphthalenyllithium 1.) THF, 25 deg C, 10 min, 2.) 25 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Ebert, Greg W.; Pfennig, Deborah R.; Suchan, Scott D.; Donovan, Thomas A.; Aouad, Emmanuel; et al.
Journal of Organic Chemistry, 1995 , vol. 60, # 8 p. 2361 - 2364
637-87-6
对氯碘苯
→
反应条件
1679-18-1
反应条件
(i) (UV-irradiation), BBr3, (ii) aq. NaOH; Multistep reaction;
参考文献
Bowie,R.A.; Musgrave,O.C.
Journal of the Chemical Society [Section] C: Organic, 1966 , p. 566 - 571
637-87-6
对氯碘苯
→
反应条件
26905-02-2
反应条件
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere 1.2: 1 h / -78 °C / |Inert atmosphere 2.1: pyridine; trichlorophosphate / 20 °C 3.1: hydrogen / methanol / 20 °C / |Inert atmosphere 4.1: trifluoroacetic acid / dichloromethane / 20 °C View Scheme
参考文献
3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.
Patent: WO2014/8197 A1, 2014 ;
637-87-6
对氯碘苯
+
141-32-2
→
反应条件
42175-12-2
反应条件
tris(dibenzylideneacetone)dipalladium (0); IPr*hydrochloride in N,N-dimethyl-formamide T=120°C; Heck reaction; 0.5 h; Inert atmosphere;
参考文献
Sobjerg, Lina Sveidal; Gauthier, Delphine; Lindhardt, Anders Thyboe; Bunge, Michael; Finster, Kai; Meyer, Rikke Louise; Skrydstrup, Troels
Green Chemistry, 2009 , vol. 11, # 12 p. 2041 - 2046
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