3-甲基-2-丁烯酸乙酯合成路线 （共 160 条）
参考文献
Mount Sinai Hospital Research Found.
Patent: US2390335 , 1941 ;
反应条件
1: 64 percent / hydrazine monohydrate / ethanol / 4 h / Heating
2: 85 percent / NaI; K2CO3 / butan-2-one / 3 h / Heating
3: 65 percent / lithium chloride / tetrahydrofuran / 12 h / 0 °C
View Scheme
参考文献
Nakano, Hiroto; Tsugawa, Natsumi; Takahashi, Kouichi; Okuyama, Yuko; Fujita, Reiko
Tetrahedron, 2006 , vol. 62, # 47 p. 10879 - 10887
反应条件
nitrogen; dibenzoyl peroxide
Erhitzen des Reaktionsprodukts mit 10percentig. wss. Natronlauge;
参考文献
Huang
Journal of the Chemical Society, 1957 , p. 1342,1347
反应条件
1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.83 h / -78 °C / |Inert atmosphere
1.2: 15 h / -78 - 20 °C / |Inert atmosphere
2.1: sodium hydroxide / ethanol; water / 48 h / |Inert atmosphere; |Reflux
2.2: pH < 1 / |Inert atmosphere
3.1: formic acid; sulfuric acid / 156 h / 20 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 3.25 h / 0 °C / |Inert atmosphere
5.1: phosphorus tribromide; pyridine / diethyl ether / 1.5 h / -78 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Froehner, Wolfgang; Reddy, Kethiri R.; Knoelker, Hans-Joachim
Arkivoc, 2012 , vol. 2012, # 3 p. 330 - 342
反应条件
chloro-trimethyl-silane; copper(l) chloride in tetrahydrofuran
Ambient temperature0.5-1.5 h;
参考文献
Cahiez, Gerard; Alami, Mouad
Tetrahedron Letters, 1990 , vol. 31, # 51 p. 7425 - 7428
反应条件
sodium ethanolate in N,N-dimethyl-formamide
T=100°C; 24 h;
参考文献
Richardson, B. Matthew; Welker, Mark E.
Journal of Organic Chemistry, 1997 , vol. 62, # 5 p. 1299 - 1304
反应条件
sodium methylate in N,N-dimethyl-formamide
参考文献
Andreeva, L. N.; Perlova, T. G.; Negrebetskii, V. V.; Dymova, S. F.; Koroleva, T. I.; et al.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 9 p. 1800 - 1801
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 9 p. 2017 - 2018
反应条件
in N,N-dimethyl-formamide
参考文献
Andreeva, L. N.; Perlova, T. G.; Negrebetskii, V. V.; Dymova, S. F.; Koroleva, T. I.; et al.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 9 p. 1800 - 1801
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 9 p. 2017 - 2018
反应条件
sodium methylate in N,N-dimethyl-formamide
different ratio of sodium methoxide to the title compounds; Product distribution;
参考文献
Andreeva, L. N.; Perlova, T. G.; Negrebetskii, V. V.; Dymova, S. F.; Koroleva, T. I.; et al.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 9 p. 1800 - 1801
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 9 p. 2017 - 2018
反应条件
1: 66 percent / calcium hypochlorite/acetic acid / CH2Cl2; H2O
2: 81 percent / tetrabutylammonium bromide, 4 N NaOH / tetrahydrofuran / Ambient temperature
View Scheme
参考文献
Mathew, Jacob; Alink, Ben
Journal of Organic Chemistry, 1990 , vol. 55, # 12 p. 3880 - 3886
