3-甲基-2-丁烯酸乙酯合成路线 （共 160 条）
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
Sandoz Ltd.
Patent: US4661617 A1, 1987 ;
反应条件
tetrachloromethane; N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile 3 h; Reflux;
参考文献
Le Baut; Sparfel; Clairc; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 5 p. 447 - 455
反应条件
1: Ca(OCl)2, AcOH / CH2Cl2 2: 78 percent / KN(SiMe3)2, hexamethylphosphoric triamide (HMPA) / tetrahydrofuran 3: 46 percent / n-BuLi, tetramethylethylenediamine (TMEDA) / tetrahydrofuran 4: 88 percent / Raney nickel / acetone View Scheme
参考文献
Mathew, Jacob; Alink, Ben
Journal of the Chemical Society, Chemical Communications, 1990 , # 9 p. 684 - 686
反应条件
1: N-bromosuccinimide, azobisisobutylnitrile / CCl4 / 3 h / Heating 2: 85.6 percent / 1.) 120 deg C, 30 min, 2.) reflux, 2 h View Scheme
参考文献
The Wellcome Foundation Limited
Patent: US5162367 A1, 1992 ;
反应条件
triethyl phosphite; dibenzoyl peroxide in benzene
参考文献
THE WELLCOME FOUNDATION LIMITED
Patent: EP251472 B1, 1991 ;
反应条件
N-bromosuccinmide 1.) CCl4; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bergdahl, Mikael; Hett, Robert; Friebe, Timothy L.; Gangloff, Anthony R.; Iqbal, Javed; et al.
Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7371 - 7374
反应条件
methylamine in ethanol
参考文献
Pfizer Limited; PFIZER INC.
Patent: EP364123 B1, 1991 ;
EP 0364123 B1
参考文献
Leonard,N.J.; Durand,D.A.
Journal of Organic Chemistry, 1968 , vol. 33, # 4 p. 1322 - 1333
参考文献
Philippi; Galter
Monatshefte fuer Chemie, 1929 , vol. 51, p. 264
反应条件
nitric acid in water 1.) 0 deg C, 1.25 h; 2.) 0 deg C, 1.5 h; 3.) room temp., 1 h;
参考文献
FUJI, Masayuki
Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 11 p. 4029 - 4036
