(4-甲基苯基)吗啉-4-基甲酮合成路线 （共 37 条）
反应条件
Zr(NMe2)4 in toluene T=90°C; 12 h; Inert atmosphere;
参考文献
Stephenson, Nickeisha A.; Zhu, Jiang; Gellman, Samuel H.; Stahl, Shannon S.
Journal of the American Chemical Society, 2009 , vol. 131, # 29 p. 10003 - 10008
反应条件
1: (4-methyl-phenyl)-(morpholin-4-yl)methanone With trichlorophosphate T=10 - 30°C; 2: 1-methylpyrrole-2-acetic acid methyl ester Product distribution / selectivity;
参考文献
MATRIX LABORATORIES LIMITED
Patent: WO2009/72139 A1, 2009 ;
Location in patent: Page/Page column 12 ;
反应条件
1: 1) POCl3 / 1) RT, 4 h, 2) 1,2-dichloroethane, 40 h 2: 50 percent / 1) POCl3 / 1) 1,2-dichloroethane, reflux, 30 min, 2) 50-60 deg C, 2 h 3: 60 percent / triton B / tetrahydrofuran / 4 h / Heating 4: 35 percent / HCl / ethanol / 70 h / Ambient temperature 5: 95.2 percent / 10percent aq. NaOH / 0.5 h / Heating View Scheme
参考文献
Artico; Corelli; Massa; Stefancich
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 6 p. 1493 - 1495
反应条件
trichlorophosphate in 1,2-dichloro-ethane
2 h; Heating;
参考文献
Tamaru, Shun-Ichi; Yu, Lianhe; Youngblood, W. Justin; Muthukumaran, Kannan; Taniguchi, Masahiko; Lindsey, Jonathan S.
Journal of Organic Chemistry, 2004 , vol. 69, # 3 p. 765 - 777
反应条件
Zr(NMe2)4 in toluene
T=25°C; 10 h; Inert atmosphere;
参考文献
Stephenson, Nickeisha A.; Zhu, Jiang; Gellman, Samuel H.; Stahl, Shannon S.
Journal of the American Chemical Society, 2009 , vol. 131, # 29 p. 10003 - 10008
反应条件
1: 1) POCl3 / 1) RT, 4 h, 2) 1,2-dichloroethane, 40 h
2: 50 percent / 1) POCl3 / 1) 1,2-dichloroethane, reflux, 30 min, 2) 50-60 deg C, 2 h
3: 60 percent / triton B / tetrahydrofuran / 4 h / Heating
View Scheme
参考文献
Artico; Corelli; Massa; Stefancich
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 6 p. 1493 - 1495
反应条件
naphthalene; lithium in tetrahydrofuran
T=-78°C; 3 h; Inert atmosphere;
参考文献
Gonzalez-Lopez, Susana; Yus, Miguel; Ramon, Diego J.
Tetrahedron Asymmetry, 2012 , vol. 23, # 8 p. 611 - 615
反应条件
trichlorophosphate
1) RT, 4 h, 2) 1,2-dichloroethane, 40 h; Yield given. Multistep reaction;
参考文献
Artico; Corelli; Massa; Stefancich
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 6 p. 1493 - 1495
反应条件
Yield given. Multistep reaction;
参考文献
Noland, Wayland E.; Lanzatella, Nicholas P.; Sizova, Elena P.; Venkatraman, Lakshmanan; Afanasyev, Oleg V.
Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 3 p. 503 - 534
反应条件
1.9 mol Au/HT; potassium tert-butylate in o-xylene
T=90°C; 36 h; Inert atmosphere;
参考文献
Zhu, Jiangling; Zhang, Yan; Shi, Feng; Deng, Youquan
Tetrahedron Letters, 2012 , vol. 53, # 25 p. 3178 - 3180
