反-4-苄氧基-3-甲氧基-β-硝基苯乙烯合成路线 （共 20 条）
反应条件
hydrogen bromide; trifluoroacetic acid T=90°C; 0.166667 h;
参考文献
Kulikov, S. V.; Samartsev, M. A.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 2.2 p. 280 - 288
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 2 p. 348 - 358
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / |Reflux 2: ethanol / 14 h / |Reflux 3: pyridine / dichloromethane / 1.5 h / 0 - 20 °C 4: trichlorophosphate / acetonitrile / 1 h / |Reflux; |Inert atmosphere 5: [[(η6-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)]Ru]; formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C 6: water; sodium hydroxide / ethanol / 3 h / 20 °C 7: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C 8: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C 9: hydrogenchloride / water; ethanol / 2 h / |Reflux View Scheme
参考文献
Sun, Haifeng; Zhu, Liyuan; Yang, Huicui; Qian, Wangke; Guo, Lin; Zhou, Shengbin; Gao, Bo; Li, Zeng; Zhou, Yu; Jiang, Hualiang; Chen, Kaixian; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 856 - 868
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / |Reflux 2: ethanol / 14 h / |Reflux 3: pyridine / dichloromethane / 1.5 h / 0 - 20 °C 4: trichlorophosphate / acetonitrile / 1 h / |Reflux; |Inert atmosphere 5: [[(η6-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)]Ru]; formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C 6: water; sodium hydroxide / ethanol / 3 h / 20 °C 7: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C 8: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C 9: hydrogenchloride / water; ethanol / 2 h / |Reflux View Scheme
参考文献
Sun, Haifeng; Zhu, Liyuan; Yang, Huicui; Qian, Wangke; Guo, Lin; Zhou, Shengbin; Gao, Bo; Li, Zeng; Zhou, Yu; Jiang, Hualiang; Chen, Kaixian; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 856 - 868
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 10 °C / Inert atmosphere; Reflux 2: 12 h / Inert atmosphere; Reflux 3: phosphorus pentachloride / chloroform; N,N-dimethyl-formamide / -78 - 20 °C / Inert atmosphere 4: sodium hydroxide / chloroform; water / Inert atmosphere View Scheme
参考文献
Li, Xiaomin; Chen, Zhengping; Tang, Jie; Liu, Chunyi; Zou, Pei; Huang, Hongbo; Tan, Cheng; Yu, Huixin
Archiv der Pharmazie, 2014 , vol. 347, # 5 p. 313 - 319
反应条件
1: With sodium tetrahydroborate in ethanol T=20°C; 2: With acetic acid; dimethyl sulfoxide; sodium nitrite T=20°C;
参考文献
Ploypradith, Poonsakdi; Petchmanee, Thaninee; Sahakitpichan, Poolsak; Litvinas, Nichole D.; Ruchirawat, Somsak
Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9440 - 9448
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h; Reflux;
参考文献
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; LIU, Hong; XIE, Xin; ZHEN, Xuechu; SUN, Haifeng; LI, Jing; ZHU, Liyuan; LI, Zeng; CHEN, Ying; JIANG, Hualiang; CHEN, Kaixian
Patent: US2014/88130 A1, 2014 ;
Location in patent: Paragraph 0087 ;
反应条件
T=15 - 20°C; Electrolysis;
参考文献
Tomita; Watanabe
Yakugaku Zasshi, 1938 , vol. 58, p. 783,486;dtsch.Ref.S.223,226
Chem. Zentralbl., 1939 , vol. 110, # I p. 1978
反应条件
1: LiAlH4 / tetrahydrofuran / 3 h / Heating
2: 78 percent / 1 h / Heating
3: BF3*OEt2; BH3*THF / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Schrittwieser, Joerg H.; Resch, Verena; Wallner, Silvia; Lienhart, Wolf-Dieter; Sattler, Johann H.; Resch, Jasmin; MacHeroux, Peter; Kroutil, Wolfgang
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6703 - 6714
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux
2.1: triethylamine / dichloromethane / 3 h / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux
4.1: sodium hydroxide / chloroform / 0 - 20 °C
5.1: trichlorophosphate / acetonitrile / 3 h / Reflux; Inert atmosphere
5.2: 20 °C / Inert atmosphere; Cooling with ice
6.1: palladium 10 on activated carbon; hydrogen; acetic acid / methanol / 16 h
7.1: berberine bridge enzyme; tris(hydroxymethyl)methylamine hydrochloride; magnesium chloride / toluene / 24 h / 40 °C / pH 9 / Darkness; Enzymatic reaction
View Scheme
参考文献
Schrittwieser, Joerg H.; Resch, Verena; Wallner, Silvia; Lienhart, Wolf-Dieter; Sattler, Johann H.; Resch, Jasmin; MacHeroux, Peter; Kroutil, Wolfgang
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6703 - 6714
反应条件
1: LiAlH4 / tetrahydrofuran / 3 h / Heating
2: 78 percent / 1 h / Heating
View Scheme
参考文献
NATIONAL TAIWAN UNIVERSITY; SU, MING-JAI; HSIN, LING-WEI
Patent: US2013/59882 A1, 2013 ;
