(9CI)-N-甲氧基-N-甲基-环丁烷羧酰胺合成路线 （共 5 条）
反应条件
1: 2-picoline With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: cyclobutanecarboxylic acid N-methoxy-N-methylamide in tetrahydrofuran; hexane T=-78°C; 3 h; Inert atmosphere;
参考文献
Muir, Calum W.; Kennedy, Alan R.; Redmond, Joanna M.; Watson, Allan J. B.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 20 p. 3337 - 3340
反应条件
pyridine
T=25°C; Inert atmosphere;
参考文献
Brachet, Etienne; Hamze, Abdallah; Peyrat, Jean-Francois; Brion, Jean-Daniel; Alami, Mouad
Organic Letters, 2010 , vol. 12, # 18 p. 4042 - 4045
反应条件
1: in tetrahydrofuran
T=-20°C; 0.0833333 h; Inert atmosphere;
2: With isopropylmagnesium chloride in tetrahydrofuran; diethyl ether
T=-20°C; 0.416667 h; Inert atmosphere;
参考文献
Muir, Calum W.; Kennedy, Alan R.; Redmond, Joanna M.; Watson, Allan J. B.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 20 p. 3337 - 3340
反应条件
N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine in dichloromethane
参考文献
Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4093 - 4102
反应条件
1: vinyl-magnesium bromide; cyclobutanecarboxylic acid N-methoxy-N-methylamide in tetrahydrofuran
T=-78°C; 0.75 h;
2: methanol With sulfuric acid in tetrahydrofuran
T=-78 - 20°C;
参考文献
Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4093 - 4102
