3-(吡啶-3-基)丙酸乙酯合成路线 （共 28 条）
参考文献
Graef et al.
Journal of Organic Chemistry, 1946 , vol. 11, p. 257,263
反应条件
hydrazine in ethanol 18 h; Heating / reflux;
参考文献
Ortho-McNeil Pharmaceutical, Inc.
Patent: US6809107 B1, 2004 ;
Location in patent: Page/Page column 80 ;
反应条件
hydrogen; sodium hexamethyldisilazane; palladium dihydroxide in tetrahydrofuran; Petroleum ether
参考文献
American Home Products Corporation
Patent: US6110962 A1, 2000 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Weller, Dwight D.; Stirchak, Eugene P.; Weller, Doreen L.
Journal of Organic Chemistry, 1983 , vol. 48, # 24 p. 4597 - 4605
反应条件
1: 3-(bromo)propionic acid ethyl ester With indium; copper(l) iodide; lithium chloride in tetrahydrofuran
T=65°C; 12 h;
2: 3-iodo-pyridine With tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl acetamide
T=90°C; 24 h;
参考文献
Shen, Zhi-Liang; Goh, Kelvin Kau Kiat; Wong, Colin Hong An; Yang, Yong-Sheng; Lai, Yin-Chang; Cheong, Hao-Lun; Loh, Teck-Peng
Chemical Communications, 2011 , vol. 47, # 16 p. 4778 - 4780
反应条件
palladium 10 on activated carbon; hydrogen in ethanol
T=20°C; 15 h;
参考文献
Voelker, Troy; Xia, Haiji; Fandrick, Keith; Johnson, Robert; Janowsky, Aaron; Cashman, John R.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 5 p. 2047 - 2068
反应条件
manganese; water; trifluoroacetic acid; Co(2,2'-bipyridine)Br2; lithium bromide in pyridine; N,N-dimethyl-formamide
参考文献
Amatore, Muriel; Gosmini, Corinne; Perichon, Jacques
Journal of Organic Chemistry, 2006 , vol. 71, # 16 p. 6130 - 6134
反应条件
potassium carbonate; dibromotriphenyl-phosphorane
T=20°C; 24 h;
参考文献
Salome, Christophe; Kohn, Harold
Tetrahedron, 2009 , vol. 65, # 2 p. 456 - 460
反应条件
1: With C16H18Cl2N2O4Pd2; potassium chloride; tetra-n-butylammonium acetate; potassium carbonate in N,N-dimethyl acetamide
T=120°C; Cacchi reaction; 14 h;
2: With hydrogenchloride in water; ethyl acetate
T=20°C; chemoselective reaction;
参考文献
Alacid, Emilio; Najera, Carmen
European Journal of Organic Chemistry, 2008 , # 18 p. 3102 - 3106
反应条件
1: conc. H2SO4
2: H2 / 5percent Pd/C / ethanol / 45 °C
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
