1-烯丙基-3,5-二甲氧基苯合成路线 （共 9 条）
反应条件
potassium permanganate; sodium periodate; potassium carbonate in water; tert-butyl alcohol T=20°C; Lemieux-van Rudloff oxidation; 4 h;
参考文献
Huang, He; Zhang, Lei; Zhang, Xiaodong; Ji, Xun; Ding, Xiao; Shen, Xu; Jiang, Hualiang; Liu, Hong
Chinese Journal of Chemistry, 2010 , vol. 28, # 6 p. 1041 - 1043
反应条件
1: 1-bromo-3,5-dimethoxybenzene With cesium fluoride; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=20°C; 0.5 h;
2: allylboronic acid pinacol ester in tetrahydrofuran
54 h; Heating / reflux;
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; RUTERGS UNIVERSITY
Patent: WO2007/8847 A2, 2007 ;
Location in patent: Page/Page column 28-30 ;
反应条件
1: vinyl-magnesium bromide With copper(l) iodide in tetrahydrofuran
T=-50°C;
2: 3,5-dimethoxy benzyl bromide in tetrahydrofuran
T=-30 - 20°C;
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/139916 A1, 2009 ;
Location in patent: Page/Page column 98 ;
WO 2009/139916 A1
反应条件
1: 3,5-dimethoxy-1-phenylmagnesium chloride With copper (I) cyanide; lithium chloride in tetrahydrofuran
T=-78°C;
2: allyl bromide in tetrahydrofuran
T=-78 - 20°C; 16 h;
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/139916 A1, 2009 ;
Location in patent: Page/Page column 95-96 ;
WO 2009/139916 A1
反应条件
magnesium; copper(I) bromide; lithium bromide
1.) THF, reflux, 4 h, 2.) THF, RT; Yield given. Multistep reaction;
参考文献
Coolen, Hein K. A. C.; Meeuwis, Johannes A. M.; Van Leeuwen, Piet W. N. M.; Nolte, Roeland J. M.
Journal of the American Chemical Society, 1995 , vol. 117, # 48 p. 11906 - 11913
反应条件
iodine; magnesium in tetrahydrofuran
T=20°C; Grignard reaction; 3 h;
参考文献
Huang, He; Zhang, Lei; Zhang, Xiaodong; Ji, Xun; Ding, Xiao; Shen, Xu; Jiang, Hualiang; Liu, Hong
Chinese Journal of Chemistry, 2010 , vol. 28, # 6 p. 1041 - 1043
反应条件
trimethylstannyl chloride; sodium; Pd(Ph-BIAN)(DMFU)
1.) liq. NH3, irradiation, 4 h; 2.) DMF, 50 deg C, overnight; Yield given. Multistep reaction;
参考文献
Dol, Georg C.; Kamer, Paul C. J.; Van Leeuwen, Piet W. N. M.
European Journal of Organic Chemistry, 1998 , # 2 p. 359 - 364
反应条件
potassium methanolate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride
1.) THF, 10 min, 2.) reflux; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Fuerstner, Alois; Seidel, Guenter
Synlett, 1998 , # 2 p. 161 - 162
参考文献
Coolen, Hein K. A. C.; Leeuwen, Piet W. N. M. van; Nolte, Roeland J. M.
Angewandte Chemie, 1992 , vol. 104, # 7 p. 906 - 909
