螺[1,3-苯并二氧戊环-2,1'-环己烷]-5-胺合成路线 （共 4 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
P=2280 Torr; 3.5 h;
参考文献
Harvison, Peter J.; Forte, Anthony J.; Nelson, Sidney D.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1737 - 1743
反应条件
1: 36.2 percent / p-TsOH / toluene / 24 h / Heating
2: 80.7 percent / 60percent aq. HNO3 / ethanol / 0.25 h / 0 °C
3: H2 / 10percent Pd/C / methanol / 3.5 h / 2280 Torr
View Scheme
参考文献
Harvison, Peter J.; Forte, Anthony J.; Nelson, Sidney D.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1737 - 1743
反应条件
1: 36.2 percent / p-TsOH / toluene / 24 h / Heating
2: 80.7 percent / 60percent aq. HNO3 / ethanol / 0.25 h / 0 °C
3: H2 / 10percent Pd/C / methanol / 3.5 h / 2280 Torr
View Scheme
参考文献
Harvison, Peter J.; Forte, Anthony J.; Nelson, Sidney D.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1737 - 1743
反应条件
1: 80.7 percent / 60percent aq. HNO3 / ethanol / 0.25 h / 0 °C
2: H2 / 10percent Pd/C / methanol / 3.5 h / 2280 Torr
View Scheme
参考文献
Harvison, Peter J.; Forte, Anthony J.; Nelson, Sidney D.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1737 - 1743
