反应条件
1: 1,1,1,3,3,3-hexamethyldisilazane, chlorotrimethyl silane / acetonitrile / 4 h / Heating
2: acetonitrile / 0.5 h / Heating
3: 90 percent / NaOMe / methanol / 24 h / Ambient temperature
4: 71 percent / pyridine / 1.25 h / Ambient temperature
5: 65 percent / tetrabutylammonium hydroxide, pyridine / acetonitrile / 48 h / Heating
6: 1.) NaH / 1.) DMF, -40 deg C, 0.75 h, 2.) DMF, a) from -40 to -30 deg C, 0.75 h, b) RT, 4 h
7: 71 percent / potassium t-butoxide / CH2Cl2 / 1.5 h / Ambient temperature
8: 75 percent / diisopropylethylamine / tetrahydrofuran / 4.5 h
View Scheme
参考文献
Lewis; Revankar; Hogan
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1309 - 1316
