3-苯基-2-异恶唑啉-5-乙酸合成路线 （共 3 条）
反应条件
sodium carbonate in tetrahydrofuran; water
12 h;
参考文献
GANIAL IMMUNOTHERAPEUTICS INC.
Patent: WO2006/97273 A1, 2006 ;
Location in patent: Page/Page column 13 ;
反应条件
1: 1.) BuLi / 1.) hexane, THF,- 20 deg C, 1 h, 2.) THF, 0 deg C, 1 h, and room temperature, 16 h.
2: dimethylformamide; H2O / 0.5 h / Heating
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参考文献
Eichinger, Karl; Wokurek, Michael; Zauner, Bernd; Rostami, Mohammad Reza
Synthetic Communications, 1997 , vol. 27, # 16 p. 2733 - 2742
参考文献
Stosic-Grujicic, Stanislava; Cvetkovic, Ivana; Mangano, Katia; Fresta, Massimo; Maksimovic-Ivanic, Danijela; Harhaji, Ljubica; Popadic, Dusan; Momcilovic, Miljana; Miljkovic, Djordje; Kim, Joseph; Al Abed, Yousef; Nicoletti, Ferdinando
Journal of Pharmacology and Experimental Therapeutics, 2007 , vol. 320, # 3 p. 1038 - 1049
