二甲基-2-(4-氰基-2-硝基苯基)丙二酸合成路线 （共 7 条）
反应条件
sulfuric acid; water; acetic acid
参考文献
Borsche; Stackmann; Makaroff-Semljanski
Chemische Berichte, 1916 , vol. 49, p. 2230
参考文献
Borsche; Stackmann; Makaroff-Semljanski
Chemische Berichte, 1916 , vol. 49, p. 2230
反应条件
1: glacial acetic acid; water; concentrated sulfuric acid 2: beim Erhitzen auf den Schmelzpunkt View Scheme
参考文献
Borsche; Stackmann; Makaroff-Semljanski
Chemische Berichte, 1916 , vol. 49, p. 2230
反应条件
1: glacial acetic acid; water; concentrated sulfuric acid 2: sulfuric acid View Scheme
参考文献
Borsche; Stackmann; Makaroff-Semljanski
Chemische Berichte, 1916 , vol. 49, p. 2230
反应条件
sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C;
参考文献
Astellas Pharma Inc.
Patent: EP2003132 A1, 2008 ;
Location in patent: Page/Page column 34 ;
EP 2003132 A1
反应条件
1: malonic acid dimethyl ester With potassium tert-butylate in dimethyl sulfoxide
T=20°C;
2: 2-chloro-5-cyano-1-nitrobenzene in dimethyl sulfoxide
T=20 - 100°C;
参考文献
Roth, Gerald J.; Heckel, Armin; Colbatzky, Florian; Handschuh, Sandra; Kley, Joerg; Lehmann-Lintz, Thorsten; Lotz, Ralf; Tontsch-Grunt, Ulrike; Walter, Rainer; Hilberg, Frank
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4466 - 4480
参考文献
Borsche; Stackmann; Makaroff-Semljanski
Chemische Berichte, 1916 , vol. 49, p. 2230
