(6a,11b,16a,17a)-6,9-二氟-11-羟基-16-甲基-3-氧代-17-(丙酰氧基)雄甾-1,4-二烯-17-羧酸合成路线 （共 10 条）
反应条件
1: With diethylamine; triethylamine in acetone T=0°C; 2.33333 h; 2: With hydrogenchloride in water pH=2;
参考文献
Alpharma APS
Patent: EP1466920 A1, 2004 ;
Location in patent: Page 7 ;
反应条件
1: With triethylamine in acetone T=10 - 30°C; 4 h; 2: With diethylamine in acetone T=10 - 20°C; 1 h;
参考文献
SUN PHARMACEUTICAL INDUSTRIES LIMITED
Patent: US2005/256325 A1, 2005 ;
Location in patent: Page/Page column 8 ;
反应条件
hydrogenchloride; triethylamine in hexadeuterioacetone; water
参考文献
US2014/148593 A1, ;
Page/Page column ;
反应条件
hydrogenchloride in hexadeuterioacetone; water
参考文献
US2014/148593 A1, ;
Page/Page column ;
反应条件
hydrogenchloride; triethylamine in water; acetone
参考文献
Barkalow, Jufang; Chamberlin, Steven A.; Cooper, Arthur J.; Hossain, Azad; Hufnagel, John J.; Langridge, Denton
Patent: US2002/133032 A1, 2002 ;
反应条件
1: 94.5 percent / periodic acid / methanol; H2O / 16 h / 20 °C 2: 1.) TEA, 2.) diisopropylamine / 1.) CH2Cl2, 0 deg C, 30 min, 2.) 20 deg C, 2 h. View Scheme
参考文献
Journal of Organic Chemistry, , vol. 51, # 12 p. 2315 - 2328
反应条件
triethylamine; tetra-(n-butyl)ammonium iodide in tetrahydrofuran T=10 - 20°C; 4 h;
参考文献
US2005/256325 A1, ;
Page/Page column 8 ;
反应条件
1: With 1-methyl-1H-imidazole in isobutyramide T=50°C; 2: With sodium hydrogensulfide in isobutyramide T=35°C; 0.25 h; 3: With hydrogenchloride in isobutyramide; water pH=2;
参考文献
EP1466920 A1, ;
Page 8 ;
反应条件
1: Et3N / CH2Cl2 / 20 °C 2: Et2NH / Heating 3: 67.1 percent / KHCO3 / dimethylformamide / 0.25 h / 22 - 25 °C View Scheme
参考文献
Phillipps; Bailey; Bain; Borella; Buckton; Clark; Doherty; English; Fazakerley; Laing; Lane-Allman; Robinson; Sandford; Sharratt; Steeples; Stonehouse; Williamson
Journal of Medicinal Chemistry, 1994 , vol. 37, # 22 p. 3717 - 3729
反应条件
1: TEA / tetrahydrofuran / 0.5 h / 20 °C
2: tetrahydrofuran; dimethylformamide / 16 h / 20 °C
View Scheme
参考文献
Kertesz, Denis J.; Marx, Michael
Journal of Organic Chemistry, 1986 , vol. 51, # 12 p. 2315 - 2328
