1: With sodium methylate in methanol T=20°C; 7 h; 2: With sodium tetrahydroborate in methanol 0.75 h; Heating; Further stages.;

lithium diisopropyl amide in tetrahydrofuran 1.) -50 deg C, 3 h, 2.) -50 deg C --> room temperature;

T=150°C; 10 h;

potassium cyanide; water in dimethyl sulfoxide 12 h; Heating; Product distribution; Further Variations:Reaction partnersReagentsSolvents;

1: 85 percent / pyridine / diethyl ether / 4 h / 0 °C 2: 1.) KOH / 1.) acetone, reflux, 2.) 2 h 3: 40 percent / lithium di-isopropylamide / tetrahydrofuran / 1.) -50 deg C, 3 h, 2.) -50 deg C --> room temperature View Scheme

1: 1.) KOH / 1.) acetone, reflux, 2.) 2 h 2: 40 percent / lithium di-isopropylamide / tetrahydrofuran / 1.) -50 deg C, 3 h, 2.) -50 deg C --> room temperature View Scheme