5-甲氧基-2,3-二氢-1H-茚-2-羧酸甲酯合成路线 （共 4 条）
反应条件
perchloric acid; palladium on activated carbon
T=20°C; P=30402 Torr; 12 h; Hydrogen atmosphere;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/80968 A1, 2004 ;
Location in patent: Page 58 ;
WO 2004/080968 A1
反应条件
perchloric acid; palladium 10 on activated carbon; hydrogen; acetic acid
16 h;
参考文献
BOGER, Dale L.
Patent: WO2012/106569 A1, 2012 ;
Location in patent: Page/Page column 102 ;
WO 2012/106569 A1
反应条件
perchloric acid; hydrogen; acetic acid
P=1551.49 Torr; 4 h;
参考文献
METABOLEX, INC.; SHI, Dong Fang; SONG, Jiangao; MA, Jingyuan; NOVACK, Aaron; PHAM, Phuongly; NASHASHIBI, Imad; RABBAT, Christopher J.; CHEN, Xin
Patent: WO2011/159297 A1, 2011 ;
Location in patent: Page/Page column 134-135 ;
WO 2011/159297 A1
反应条件
1.1: sodium hydride / tetrahydrofuran
1.2: 12 h / 0 °C / Reflux
1.3: pH 7
2.1: hydrogen / perchloric acid; palladium 10 on activated carbon / acetic acid / 16 h
View Scheme
参考文献
BOGER, Dale L.
Patent: WO2012/106569 A1, 2012 ;
WO 2012/106569 A1
