4-[4-(4-氯苯基)-4-羟基-1-哌啶基]-2,2-二苯基丁酰胺合成路线 （共 5 条）
反应条件
potassium hydroxide in dimethyl sulfoxide T=80°C; 24 h; Inert atmosphere;
参考文献
Lazarova, Neva; Zoghbi, Sami S.; Hong, Jinsoo; Seneca, Nicholas; Tuan, Ed; Gladding, Robert L.; Liow, Jeih-San; Taku, Andrew; Innis, Robert B.; Pike, Victor W.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 19 p. 6034 - 6043
反应条件
potassium hydroxide in tert-butyl alcohol
T=100°C; 72 h; Inert atmosphere;
参考文献
Bao, Xiaofeng; Liu, Duliang
Tetrahedron Letters, 2013 , vol. 54, # 11 p. 1412 - 1415
反应条件
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / |Inert atmosphere; |Schlenk technique
2: potassium hydroxide / tert-butyl alcohol / 72 h / 100 °C / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Bao, Xiaofeng; Liu, Duliang; Jin, Yanyan; Yang, Yao
Molecules, 2012 , vol. 17, # 12 p. 14288 - 14297
反应条件
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / |Inert atmosphere; |Schlenk technique
2: potassium hydroxide / tert-butyl alcohol / 72 h / 100 °C / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Bao, Xiaofeng; Liu, Duliang; Jin, Yanyan; Yang, Yao
Molecules, 2012 , vol. 17, # 12 p. 14288 - 14297
反应条件
1: sodium iodide; sodium carbonate / acetonitrile / |Reflux
2: potassium hydroxide; tert-butyl alcohol / 48 h / |Reflux
View Scheme
参考文献
Wang, Min; Gao, Mingzhang; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5259 - 5263
