2-苯基乙基丙二酸二乙酯合成路线 （共 27 条）
反应条件
ammonium cerium(IV) nitrate in acetic acid T=80°C; 3 h; further reagents, temperatures, solvents; also further ω-phenylalkyldicarbonyl compounds; Product distributionMechanism;
参考文献
Holzgrabe; Reinhardt; Zlotos
Archiv der Pharmazie, 1994 , vol. 327, # 8 p. 515 - 523
反应条件
ammonium cerium(IV) nitrate T=80°C;
参考文献
Holzgrabe; Reinhardt; Zlotos
Archiv der Pharmazie, 1994 , vol. 327, # 8 p. 515 - 523
反应条件
1: With water; sodium hydroxide in tetrahydrofuran; methanol
0.5 h; Reflux;
2: With hydrogenchloride in tetrahydrofuran; methanol; water
pH=< 1;
参考文献
Orrling, Kristina M.; Marzahn, Melissa R.; Gutierrez-de-Teran, Hugo; Aqvist, Johan; Dunn, Ben M.; Larhed, Mats
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 16 p. 5933 - 5949
反应条件
sodium ethanolate in ethanol
T=40°C;
参考文献
Wu, Zhixing; Minhas, Gurpreet Singh; Wen, Dingyi; Jiang, Hualiang; Chen, Kaixian; Zimniak, Piotr; Zheng, Jiang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 12 p. 3282 - 3294
反应条件
2: sodium ethylate; toluene
View Scheme
参考文献
Blicke; Zienty
Journal of the American Chemical Society, 1941 , vol. 63, p. 2991
反应条件
1: sodium ethylate; ethanol / anschliessend Erwaermen mit Isobutylbromid
2: aqueous ethanol
View Scheme
参考文献
Blicke; Centolella
Journal of the American Chemical Society, 1938 , vol. 60, p. 2923
反应条件
2: aqueous HBr
View Scheme
参考文献
Ansell; Hey
Journal of the Chemical Society, 1950 , p. 1683,1684
