N-Boc-L-苯丙氨醇合成路线 （共 89 条）
反应条件
1: base 2: LiAlH4 / tetrahydrofuran 3: H2 / (S,S)-[(Et-DuPHOS)Rh(COD)]OTf / tetrahydrofuran / 12 h / 20 - 25 °C / 1551.44 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 36 p. 6685 - 6688
反应条件
1: LiAlH4 / tetrahydrofuran 2: H2 / (S,S)-[(Et-DuPHOS)Rh(COD)]OTf / tetrahydrofuran / 12 h / 20 - 25 °C / 1551.44 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 36 p. 6685 - 6688
参考文献
Warner-Lambert Company
Patent: US5631281 A1, 1997 ;
反应条件
triethylamine in tetrahydrofuran T=20°C; 16 h;
参考文献
Barfoot, Christopher W.; Harvey, Joanne E.; Kenworthy, Martin N.; Kilburn, John Paul; Ahmed, Mahmood; Taylor, Richard J.K.
Tetrahedron, 2005 , vol. 61, # 13 p. 3403 - 3417
反应条件
1: Et3N; DMAP / CH2Cl2 / 2 h / 20 °C 2: NaBH4 View Scheme
参考文献
Organic letters, , vol. 3, # 6 p. 897 - 899
反应条件
1.1: D-proline / acetonitrile / 3 h / 0 - 20 °C 1.2: NaBH4 / acetonitrile; ethanol / 0.08 h / 0 °C 2.1: 70 percent / Raney-Nickel; AcOH; hydrogen / methanol / 16 h / 20 °C / 3102.97 Torr 3.1: 0.1 g / triethylamine / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Tetrahedron, , vol. 63, # 39 p. 9758 - 9763
反应条件
1: 92 percent / 1M NaOH / dioxane / 6 h / pH 8 2: 72 percent / NaBH4; LiI / 1,2-dimethoxy-ethane / 2.5 h / 40 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 10 p. 1903 - 1915
反应条件
1: 100 percent / Et3N / CH2Cl2 / 24 h / Ambient temperature 2: diisobutylaluminium hydride / hexane; CH2Cl2 / 0.1 h / -78 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 30, # 10 p. 789 - 800
反应条件
sodium tetrahydroborate in methanol T=20°C;
参考文献
Journal of Chemical Research, , # 12 p. 683 - 685
反应条件
sodium tetrahydroborate in tetrahydrofuran; water T=0°C; 0.0833333 h;
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 49, # 10 p. 1372 - 1378
