二氟溴乙酸乙酯合成路线

VERTEX PHARMACEUTICALS INCORPORATED; LI, Pan; WAAL, Nathan; RONKIN, Steven; TANG, Qing; LAUFFER, David
Patent: WO2010/138663 A1, 2010 ;
Location in patent: Page/Page column 25-26 ;
WO 2010/138663 A1

667-27-6二氟溴乙酸乙酯+

15186-48-8(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-甲醛

95058-92-7二氟-羟基-(亚异丙基二氧丙基)-丙酸乙酯

参考文献

PHARMAESSENTIA CORP.
Patent: WO2006/119347 A1, 2006 ;
Location in patent: Page/Page column 9-10 ;

667-27-6二氟溴乙酸乙酯+

15186-48-8(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-甲醛

参考文献

HANMI PHARM. CO., LTD.
Patent: WO2006/9353 A1, 2006 ;
Location in patent: Page/Page column 11-12 ;