4-(氯甲基)-2-(2-氟苯)-5-甲基-1,3-恶唑合成路线 （共 2 条）
反应条件
trichlorophosphate in acetonitrile
T=0 - 20°C;
参考文献
Shibata, Yoshihiro; Kagechika, Katsuji; Yamaguchi, Mitsuhiro; Yoshikawa, Kenji; Chiba, Kiyoshi; Takano, Hiromichi; Akiyama, Chiyuki; Ono, Mayumi; Nishi, Mina; Kubo, Hideo; Kobayashi, Yoshimasa; Usui, Hiroyuki
Chemical and Pharmaceutical Bulletin, 2013 , vol. 61, # 12 p. 1248 - 1263
反应条件
1: HCl; AcOH / 0 °C
2: POCl3 / CHCl3 / Heating
View Scheme
参考文献
Kuhn, Bernd; Hilpert, Hans; Benz, Joerg; Binggeli, Alfred; Grether, Uwe; Humm, Roland; Maerki, Hans Peter; Meyer, Markus; Mohr, Peter
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4016 - 4020
