4,6-二氯-1H-吡咯并[3,2-C吡啶合成路线 （共 4 条）
反应条件
in tetrahydrofuran T=-78°C; 1 h;
参考文献
SYNGENTA PARTICIPATIONS AG; EDMUNDS, Andrew; BIGOT, Aurelien; HALL, Roger Graham; JEANGUENAT, André; LUKSCH, Torsten; RENDLER, Sebastian
Patent: WO2013/156431 A1, 2013 ;
Location in patent: Page/Page column 52 ;
反应条件
1: 90 percent / KOH, cryptand TDA-1 / acetonitrile / 0.75 h / Ambient temperature 2: 72 percent / NH3 / methanol / 12 h / 50 °C 3: N2H4 / 1 h / 80 °C 4: Raney nickel / ethanol / 2 h / Heating View Scheme
参考文献
Seela; Bourgeois
Synthesis, 1988 , # 12 p. 938 - 943
反应条件
1: 90 percent / KOH, cryptand TDA-1 / acetonitrile / 0.75 h / Ambient temperature 2: 72 percent / NH3 / methanol / 12 h / 50 °C 3: N2H4 / 1 h / 80 °C 4: Raney nickel / ethanol / 2 h / Heating 5: 40 percent / NH3, H2 / 10percent Pd/C / methanol / 30 h / Ambient temperature View Scheme
参考文献
Seela; Bourgeois
Synthesis, 1988 , # 12 p. 938 - 943
反应条件
sodium hydride in tetrahydrofuran; mineral oil T=0 - 20°C; 5.5 h;
参考文献
Haynes, Nancy-Ellen; Hermann, Johannes; Kim, Kyungjin; Scott, Nathan Robert; Yi, Lin; Zak, Mark
Patent: US2013/331375 A1, 2013 ;
Location in patent: Paragraph 0172 ;
