6-溴-1,1-二甲基-2,3-二氢-1H-茚合成路线 （共 5 条）
反应条件
1: dimethyl zinc With titanium tetrachloride in dichloromethane; toluene
T=-40°C; 0.333333 h;
2: 6-bromoindan-1-one in dichloromethane; toluene
T=-40 - 20°C;
参考文献
Augeri, David John; Bagdanoff, Jeffrey Thomas; Baugh, Simon David Peter; Carlsen, Marianne; Carson, Kenneth Gordon; Gilleran, John Anthony; He, Wei; Oravecz, Tamas; Salojin, Konstantin; Sung, Leonard
Patent: US2012/225857 A1, 2012 ;
Location in patent: Page/Page column 24 ;
反应条件
1: With dimethyl zinc; titanium tetrachloride in dichloromethane; toluene
T=-40°C; 0.333333 h;
2: 6-bromoindan-1-one in dichloromethane; toluene
T=-40 - 20°C; 18 h;
参考文献
ALLERGAN, INC.
Patent: WO2005/66115 A2, 2005 ;
Location in patent: Page/Page column 27-28 ;
反应条件
sulfuric acid
T=50°C; 0.166667 h;
参考文献
Miller, Kenneth J.; Moschner, Karl F.; Potts, Kevin T.
Journal of the American Chemical Society, 1983 , vol. 105, # 7 p. 1705 - 1712
反应条件
1: 1.) Mg / 1.) ether, -40 to -30 deg C, 2.) ether, room temperature, overnight
2: 73 percent / 90percent H2SO4 / 0.17 h / 50 °C
View Scheme
参考文献
Miller, Kenneth J.; Moschner, Karl F.; Potts, Kevin T.
Journal of the American Chemical Society, 1983 , vol. 105, # 7 p. 1705 - 1712
反应条件
magnesium
1.) ether, reflux, 2 h, 2.) ether; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Miller, Kenneth J.; Moschner, Karl F.; Potts, Kevin T.
Journal of the American Chemical Society, 1983 , vol. 105, # 7 p. 1705 - 1712
