5-溴-2-氯-3-硝基吡啶合成路线 （共 46 条）
反应条件
1: ethanol; tin(ll) chloride / 1 h / Reflux 2: pyridine / pyridine / 0.67 h / 0 - 20 °C View Scheme
参考文献
CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.
Patent: US2012/238587 A1, 2012 ;
US 20120238587 A1
反应条件
1: water; tetrahydrofuran / 12 h / 20 °C 2: SnCl2·2H2O / ethyl acetate / 3.5 h / Reflux 3: 3 h / Reflux View Scheme
参考文献
MERZ PHARMA GMBH and CO. KGAA; HENRICH, Markus; WEIL, Tanja; HECHENBERGER, Mirko; MUeLLER, Sibylle; KAUSS, Valerjans; ZEMRIBO, Ronalds; ERDMANE, Elina; SMITS, Gints
Patent: WO2011/15343 A1, 2011 ;
WO 2011/015343 A1
反应条件
in dimethyl sulfoxide T=23°C; 20 h;
参考文献
US2010/331293 A1, ;
Page/Page column 68 ;
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 40 °C / Inert atmosphere 2: hydrogenchloride / water / 110 °C / Inert atmosphere 3: water; iron; acetic acid / 1.25 h / 20 °C / Inert atmosphere; Cooling View Scheme
参考文献
PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung
Patent: WO2011/58473 A1, 2011 ;
反应条件
in tetrahydrofuran T=-78 - -20°C; 8 h;
参考文献
Zhang, Zhongxing; Yang, Zhong; Meanwell, Nicholas A.; Kadow, John F.; Wang, Tao
Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2345 - 2347
反应条件
1.1: sodium hydride / N,N-dimethyl-aniline / 0.17 h / |Inert atmosphere 1.2: 3 h / 40 °C 2.1: hydrogenchloride; water / 5 h / |Reflux 3.1: N,N-dimethyl-formamide / 4.25 h / 90 °C / |Inert atmosphere 4.1: acetic acid; iron / 100 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; MCCOMAS, Casey Cameron; LIVERTON, Nigel J.; HABERMANN, Joerg; KOCH, Uwe; NARJES, Frank; LI, Peng; PENG, Xuanjia; SOLL, Richard; WU, Hao; PALANI, Anandan; DAI, Xing; LIU, Hong; HE, Shuwen; DANG, Qung
Patent: WO2013/34048 A1, 2013 ;
反应条件
in 1,4-dioxane T=120°C; 26.5 h;
参考文献
US2004/110785 A1, ;
Page 78-79 ;
反应条件
1: With sodium hydride in tetrahydrofuran T=20°C; 3.5 h; 2: With hydrogenchloride; water Heating / reflux; 3: With water; sodium carbonate pH=9;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/157191 A2, 2008 ;
Location in patent: Page/Page column 83-84 ;
WO 2008/157191 A2
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 40 °C / Inert atmosphere 2: hydrogenchloride / water / 110 °C / Inert atmosphere View Scheme
参考文献
PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung
Patent: WO2011/58473 A1, 2011 ;
反应条件
1: iron-turnings; acetic acid 2: sodium nitrite; aqueous hydrochloric acid; copper-powder / Diazotization View Scheme
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
