N-(2,4-二氯-5-羟基苯基)乙酰胺合成路线 （共 12 条）
反应条件
sulfuryl dichloride in formic acid; water
参考文献
Clariant GmbH
Patent: US6242646 B1, 2001 ;
反应条件
chlorine; acetic acid T=15 - 20°C;
参考文献
Journal of the American Chemical Society, , vol. 41, p. 460
参考文献
Organic Process Research and Development, , vol. 5, # 6 p. 593 - 598
参考文献
Journal of the American Chemical Society, , vol. 41, p. 460
参考文献
Shapiro, Rafael; DiCosimo, Robert; Hennessey, Susan M.; Stieglitz, Barry; Campopiano, Onorato; Chiang, George C.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 593 - 598
反应条件
1: KOH-solution 2: hydrochloric acid View Scheme
参考文献
Jacobs; Heidelberger; Rolf
Journal of the American Chemical Society, 1919 , vol. 41, p. 460
反应条件
potassium carbonate in acetone
参考文献
FMC Corporation
Patent: US5136868 A1, 1992 ;
参考文献
Jacobs; Heidelberger; Rolf
Journal of the American Chemical Society, 1919 , vol. 41, p. 460
反应条件
1.1: hydrogenchloride / methanol; water / 2 h / 75 °C / |Inert atmosphere
2.1: sodium nitrite / water / 1.25 h / 0 - 5 °C / |Inert atmosphere
2.2: 1 h / 0 - 65 °C
2.3: 1 h / 40 - 50 °C
3.1: sodium acetate / methanol / 1.33 h / -10 - 0 °C
4.1: acetic acid / ethyl acetate / 4 h / 65 - 70 °C
View Scheme
参考文献
Shapiro, Rafael; DiCosimo, Robert; Hennessey, Susan M.; Stieglitz, Barry; Campopiano, Onorato; Chiang, George C.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 593 - 598
反应条件
1.1: potassium hydroxide; potassium carbonate; tetraethylammonium bromide / water / 1.33 h / 65 - 75 °C
2.1: hydrogenchloride / methanol; water / 2 h / 75 °C / |Inert atmosphere
3.1: sodium nitrite / water / 1.25 h / 0 - 5 °C / |Inert atmosphere
3.2: 1 h / 0 - 65 °C
3.3: 1 h / 40 - 50 °C
4.1: sodium acetate / acetonitrile / 0.5 h / 20 °C
4.2: 1 h / 0 - 5 °C
5.1: acetic acid / toluene / 1 h / |Reflux
View Scheme
参考文献
Shapiro, Rafael; DiCosimo, Robert; Hennessey, Susan M.; Stieglitz, Barry; Campopiano, Onorato; Chiang, George C.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 593 - 598
