反应条件
1: 75 percent / i-Pr2NEt, Pd(OAc)2, Ph3P / dimethylformamide / 14 h / 80 °C
2: 1.) O3, 2.) NaBH4 / 1.) CH2Cl2, -78 deg C, 2.) MeOH, RT, 12 h
3: lipase / diethyl ether / 6 h / Ambient temperature
4: 73 percent / Et3N, 4-DMAP / CH2Cl2 / 3 h / Ambient temperature
5: 78 percent / NaBH4 / dimethylsulfoxide / 26 h / 60 °C
View Scheme
参考文献
Bando, Toshikazu; Namba, Yukiko; Shishido, Kozo
Tetrahedron Asymmetry, 1997 , vol. 8, # 13 p. 2159 - 2165
