potassium tert-butylate in tetrahydrofuran 2 h; Heating;

1.1: LDA / tetrahydrofuran / 0.67 h / -78 - 0 °C 1.2: 92 percent / tetrahydrofuran / 2 h / -78 °C 2.1: potassium t-butoxide / tetrahydrofuran / 1 h / 20 °C 2.2: 93 percent / tetrahydrofuran / 2 h / Heating View Scheme

1.1: LDA / tetrahydrofuran / 0.67 h / -78 - 0 °C 1.2: 92 percent / tetrahydrofuran / 2 h / -78 °C 2.1: potassium t-butoxide / tetrahydrofuran / 1 h / 20 °C 2.2: 93 percent / tetrahydrofuran / 2 h / Heating View Scheme

1: 91 percent / TFA / 1 h / Heating 2: 91 percent / m-chloroperbenzoic acid, sodium carbonate / CH2Cl2 / 72 h / Ambient temperature 3: 89 percent / BuLi / tetrahydrofuran / 1 h / Ambient temperature 4: 79 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) reflux, 2 h View Scheme

1: 91 percent / m-chloroperbenzoic acid, sodium carbonate / CH2Cl2 / 72 h / Ambient temperature 2: 89 percent / BuLi / tetrahydrofuran / 1 h / Ambient temperature 3: 79 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) reflux, 2 h View Scheme

1: 89 percent / BuLi / tetrahydrofuran / 1 h / Ambient temperature 2: 79 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) reflux, 2 h View Scheme

72 h; Irradiation; Yield given;