7-氯-1-乙基-6-氟-1,4-二氢-4-羰基喹啉-3-羧酸合成路线 （共 26 条）
反应条件
in water; acetonitrile
参考文献
Korea Institute of Science and Technology
Patent: US5051505 A1, 1991 ;
反应条件
in acetic acid; dimethyl sulfoxide
参考文献
Laboratorie Roger Bellon; Dainippon Pharmaceutical
Patent: US4292317 A1, 1981 ;
US 4292317 A
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
in water 13 h; Heating;
参考文献
Abaee, M. Saeed; Sharifi, Ruhollah; Borhani, Shahin; Heravi, Majid M.; Motahari, Hossein
Heterocyclic Communications, 2005 , vol. 11, # 5 p. 415 - 418
反应条件
1: 66 percent / 5 h / 130 - 140 °C 2: 85 percent / 87percent HCOOH / Heating View Scheme
参考文献
Koga, Hiroshi; Itoh, Akira; Murayama, Satoshi; Suzue, Seigo; Irikura, Tsutomu
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1358 - 1363
反应条件
pyridine; sodium hydroxide in P2O5; ethanol; water; acetic acid; N,N-dimethyl-formamide
参考文献
Laboratorie Roger Bellon; Dainippon Pharmaceutical
Patent: US4292317 A1, 1981 ;
US 4292317 A
反应条件
tetra-n-butylammonium fluoride trihydrate in pyridine; water
参考文献
Korea Institute of Science and Technology
Patent: US5051505 A1, 1991 ;
反应条件
in ethanol T=120°C; 0.583333 h; Microwave irradiation;
参考文献
Amarante, Giovanni W.; Benassi, Mario; Pascoal, Robert N.; Eberlin, Marcos N.; Coelho, Fernando
Tetrahedron, 2010 , vol. 66, # 24 p. 4370 - 4376
反应条件
in sodium hydroxide; water
参考文献
Kyorin Seiyaku Kabushiki Kaisha
Patent: US4448962 A1, 1984 ;
反应条件
in water 16 h; Heating;
参考文献
Abaee, M. Saeed; Sharifi, Ruhollah; Borhani, Shahin; Heravi, Majid M.; Motahari, Hossein
Heterocyclic Communications, 2005 , vol. 11, # 5 p. 415 - 418
