3,5-dimethoxyaniline hydrobromide in various solvent(s) T=80°C; 2 h;

1: 5-chloro-1,3-dimethoxybenzene With BrettPhos Palladacycle; sodium t-butanolate; hydrazine in tetrahydrofuran T=20°C; 0.025 h; Flow reactorSonicationInert atmosphere; 2: cyclohexanone With trifluoroacetic acid in THF-d8 (tetrahydrofuran-d8); water T=125°C; 0.1 h; Flow reactorSonicationInert atmosphere;

acetic acid T=80 - 85°C; 1 h;