1-(6-二甲胺基萘-2-基)乙酮合成路线 （共 10 条）
反应条件
1: dimethyl amine With lithium in N,N,N',N',N'',N''-hexamethylphosphoric triamide; toluene T=20°C; 1.5 h; 2: 1-(6-methoxy-2-naphthyl)-1-ethanone in N,N,N',N',N'',N''-hexamethylphosphoric triamide; toluene T=20°C; 20 h;
参考文献
Barrio, Jorge R.; Petric, Andre J.; Satyamurthy, Nagichettiar; Kepe, Vladimir; Small, Gary W.
Patent: US2007/53831 A1, 2007 ;
Location in patent: Page/Page column 6 ;
反应条件
N,N'-dimethyl-N,N'-propyleneurea in hexane T=20°C; 16 h;
参考文献
Nitz, Mark; Mezo, Adam R; Ali, Mayssam H; Imperiali, Barbara
Chemical communications (Cambridge, England), 2002 , # 17 p. 1912 - 1913
反应条件
1: With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; ethylene glycol; triethylamine T=24 - 145°C; Inert atmosphere; 2: With hydrogenchloride in dichloromethane; water T=24°C; 1 h; Inert atmosphere;
参考文献
Rao, Alla Sreenivasa; Kim, Dokyoung; Wang, Taejun; Kim, Ki Hean; Hwang, Sekyu; Ahn, Kyo Han
Organic Letters, 2012 , vol. 14, # 10 p. 2598 - 2601
反应条件
1.1: sodium disulfite / water / 145 °C / Inert atmosphere; sealed tube 2.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; ethylene glycol; triethylamine / 24 - 145 °C / Inert atmosphere 2.2: 1 h / 24 °C / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 14, # 10 p. 2598 - 2601
反应条件
1: 1-(6-methoxy-2-naphthyl)-1-ethanone With hydrogenchloride; triethylamine in dichloromethane; water T=85°C; 2: dimethylammonium chloride With Na2S2O5; sodium hydroxide in water T=140°C; 48 h; Autoclave;
参考文献
Yao, Wei; Yan, Yongli; Xue, Lin; Zhang, Chuang; Li, Guoping; Zheng, Qingdong; Zhao, Yong Sheng; Jiang, Hua; Yao, Jiannian
Angewandte Chemie - International Edition, 2013 , vol. 52, # 33 p. 8713 - 8717
Angew. Chem., 2013 , vol. 125, # 33 p. 8875 - 8879,5
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=75°C; 9 - 13 h;
参考文献
Chemical Communications, , vol. 50, # 3 p. 289 - 291
反应条件
1: acetic acid; hydrogen bromide / water / 12 h / 100 °C 2: Na2S2O5; ammonium hydroxide / water / 96 h / 100 °C 3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 9 - 13 h / 75 °C View Scheme
参考文献
Chemical Communications, , vol. 50, # 3 p. 289 - 291
反应条件
1: Na2S2O5; ammonium hydroxide / water / 96 h / 100 °C 2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 9 - 13 h / 75 °C View Scheme
参考文献
Chemical Communications, , vol. 50, # 3 p. 289 - 291
反应条件
1: conc. sulfuric acid; bromine / tetrahydrofuran / 4 h / 20 °C 2: 110 mg / diethyl phosphite; DIPEA / tetrahydrofuran / 20 °C View Scheme
参考文献
Liu, Qing; Xue, Lin; Zhu, Dong-Jian; Li, Guo-Ping; Jiang, Hua
Chinese Chemical Letters, 2014 , vol. 25, # 1 p. 19 - 23
反应条件
potassium hydroxide in N,N-dimethyl-formamide
T=65 - 68°C; alkaline cleavage; 12 h;
参考文献
Zabjek, Alenka; Petric, Andrej
Tetrahedron Letters, 1999 , vol. 40, # 33 p. 6077 - 6078
