1: 1-methylguanidine hydrochloride With copper(l) iodide; caesium carbonate in N,N-dimethyl-formamide T=40°C; 0.25 h; Inert atmosphere; 2: 2-bromo-1-cyclohexene-1-carboxylic acid in N,N-dimethyl-formamide T=40°C; 2 h; Inert atmosphere;

caesium carbonate in N,N-dimethyl-formamide T=20°C; 10 h; Inert atmosphereSealed tube;

1,3-bis-(diphenylphosphino)propane; acetic acid; triethylamine; palladium dichloride T=120°C; P=7600.51 Torr; 3 h; Autoclave; SolventReagent/catalyst;

sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide in acetonitrile T=10°C; 2 h;

sodium hydroxide in methanol; water T=20°C; 4 h;

1: phosphorus tribromide / chloroform 2: sodium chlorite; dihydrogen peroxide View Scheme