5-溴-2-(4-甲氧基苯氧基)嘧啶合成路线 (共 3 条)
反应条件
tetrakis(triphenylphosphine) palladium(0); oxygen; caesium carbonate in ethylene glycol dimethyl ether; water
T=20°C; 10 h;
参考文献
Bardhan, Sujata; Wacharasindhu, Sumrit; Wan, Zhao-Kui; Mansour, Tarek S.
Organic Letters, 2009 , vol. 11, # 12 p. 2511 - 2514
反应条件
1: 5-bromopyrimidin-2-one With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate in tetrahydrofuran
T=20°C; 0.833333 h; Inert atmosphere;
2: 4-methoxy-phenol With caesium carbonate in tetrahydrofuran
T=20°C; 0.75 h;
参考文献
Kokatla, Hari Prasad; Lakshman, Mahesh K.
Organic Letters, 2010 , vol. 12, # 20 p. 4478 - 4481
反应条件
sodium hydroxide; potassium carbonate in water
参考文献
ICI Australia Limited
Patent: US4248618 A1, 1981 ;