(6-碘苯并[1,3]二氧杂环戊烯-5-基)甲醇合成路线 （共 16 条）
反应条件
1: 93 percent / pyridinium chlorochromate / CH2Cl2 / 16 h / 18 °C 2: 88 percent / acetic acid; sodium cyanide; MnO2 / CHCl3 / 16 h / 18 °C 3: 24 percent / triethylamine / PdCl2(dppf) / acetonitrile / 0.25 h / 80 °C / microwave irradiation View Scheme
参考文献
Matveenko, Maria; Kokas, Okanya J.; Banwell, Martin G.; Willis, Anthony C.
Organic Letters, 2007 , vol. 9, # 18 p. 3683 - 3685
反应条件
iodine; silver trifluoroacetate in chloroform
T=20°C;
参考文献
Harrowven, David C.; Nunn, Michael I.T.; Fenwick, David R.
Tetrahedron Letters, 2002 , vol. 43, # 41 p. 7345 - 7347
反应条件
zinc; CoI2(dppe) in acetonitrile
T=80°C; 3 h;
参考文献
Chang, Kuo-Jui; Rayabarapu, Dinesh Kumar; Cheng, Chien-Hong
Journal of Organic Chemistry, 2004 , vol. 69, # 14 p. 4781 - 4787
反应条件
zinc; CoI2(dppe) in acetonitrile
T=80°C; 3 h;
参考文献
Chang, Kuo-Jui; Rayabarapu, Dinesh Kumar; Cheng, Chien-Hong
Journal of Organic Chemistry, 2004 , vol. 69, # 14 p. 4781 - 4787
反应条件
diisobutylaluminium hydride in toluene
T=-78°C; 0.5 h;
参考文献
Abe, Hitoshi; Takeda, Shigemitsu; Takeuchi, Yasuo; Harayama, Takashi
Heterocycles, 2003 , vol. 61, p. 521 - 528
反应条件
sodium tetrahydroborate in isopropyl alcohol
16 h; Heating;
参考文献
Bogucki; Charlton
Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 588 - 593
反应条件
zinc; CoI2(dppe) in acetonitrile
T=80°C; 3 h;
参考文献
Chang, Kuo-Jui; Rayabarapu, Dinesh Kumar; Cheng, Chien-Hong
Journal of Organic Chemistry, 2004 , vol. 69, # 14 p. 4781 - 4787
反应条件
sodium methylate in dimethyl sulfoxide
T=150°C;
参考文献
Kobayashi, Shigeru; Imakura, Yasuhiro; Horikawa, Ritsuko
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 4 p. 1287 - 1293
反应条件
1: n-BuLi, I2 / hexane; tetrahydrofuran
2: 20percent aq. HCl / methanol; benzene / 16 h
3: 97 percent / NaBH4 / propan-2-ol / 16 h / Heating
View Scheme
参考文献
Bogucki; Charlton
Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 588 - 593
反应条件
1: p-TsOH / benzene / 15 h / Heating
2: n-BuLi, I2 / hexane; tetrahydrofuran
3: 20percent aq. HCl / methanol; benzene / 16 h
4: 97 percent / NaBH4 / propan-2-ol / 16 h / Heating
View Scheme
参考文献
Bogucki; Charlton
Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 588 - 593
