1,1-环丙烷二甲酸二甲酯合成路线 （共 18 条）
反应条件
sodium hydroxide in water T=40°C; 2 h;
参考文献
Organic Process Research and Development, , vol. 11, # 2 p. 200 - 205
反应条件
hydrogenchloride; sodium hydroxide; ammonia in methanol
参考文献
Huels Aktiengesellschaft
Patent: US5569781 A1, 1996 ;
反应条件
sodium hydroxide in methanol
参考文献
Charton, Yves; Guillonneau, Claude; Lockhart, Brian; Lestage, Pierre; Goldstein, Solo
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 6 p. 2188 - 2193
反应条件
sodium hydroxide in water T=40°C; 2 h;
参考文献
Organic Process Research and Development, , vol. 11, # 2 p. 200 - 205
反应条件
hydrogenchloride; sodium hydroxide; ammonia in methanol
参考文献
Huels Aktiengesellschaft
Patent: US5569781 A1, 1996 ;
反应条件
Wilkinson's catalyst; acetic acid in tetrahydrofuran T=200°C; 4 h;
参考文献
Dzhemilev, U. M.; Khusnutdinov, R. I.; Shchadneva, N. A.; Tolstikov, G. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 7.2 p. 1447 - 1450
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 7 p. 1598 - 1601
反应条件
1: With diisobutylaluminium hydride in dichloromethane
T=-78°C; 7 h;
2: With hydrogenchloride; ammonium chloride in dichloromethane; water
T=-78 - 20°C;
参考文献
ELI LILLY AND COMPANY; COATES, David, Andrew; GILMOUR, Raymond; MARTIN, Jose, Alfredo; MARTIN DE LA NAVA, Eva, Maria
Patent: WO2012/74761 A1, 2012 ;
反应条件
1.1: sodium hydroxide / water; methanol / 20 °C
1.2: pH 2 - 3
2.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / -10 °C
2.2: 2.5 h / Cooling with ice
View Scheme
参考文献
ELI LILLY AND COMPANY; COATES, David, Andrew; GILMOUR, Raymond; MARTIN, Jose, Alfredo; MARTIN DE LA NAVA, Eva, Maria
Patent: WO2012/74761 A1, 2012 ;
