N-甲氧基-N-甲基苯甲酰胺合成路线 （共 140 条）
反应条件
in tetrahydrofuran T=20°C; 1 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; BROWN, Jason, W.; KEUNG, Walter; LI, Zhe; TYHONAS, John
Patent: WO2010/111634 A2, 2010 ;
Location in patent: Page/Page column 163-164 ;
WO 2010/111634 A2
反应条件
1: N-Methoxy-N-methyl-benzamide; vinyl-magnesium bromide in tetrahydrofuran T=0 - 20°C; 1.16667 h; 2: benzyl-methyl-amine in tetrahydrofuran; water T=20°C; 0.333333 h; Further stages.;
参考文献
Gomtsyan; Koenig; Lee
Journal of Organic Chemistry, 2001 , vol. 66, # 10 p. 3613 - 3616
反应条件
1: phenylacetylene With n-butyllithium in tetrahydrofuran; hexane T=-40 - -15°C; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=-78 - 22°C;
参考文献
Friel, Donna K.; Snapper, Marc L.; Hoveyda, Amir H.
Journal of the American Chemical Society, 2008 , vol. 130, # 30 p. 9942 - 9951
反应条件
in tetrahydrofuran T=65°C; 1.5 h;
参考文献
Nahm, Steven; Weinreb, Steven M.
Tetrahedron Letters, 1981 , vol. 22, # 39 p. 3815 - 3818
反应条件
in tetrahydrofuran T=20°C; 1 h;
参考文献
Nahm, Steven; Weinreb, Steven M.
Tetrahedron Letters, 1981 , vol. 22, # 39 p. 3815 - 3818
反应条件
1: in tetrahydrofuran T=0 - 20°C; Weinreb ketone synthesis; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water pH=2; Inert atmosphere;
参考文献
Uehara, Kazuhiro; Wagner, Christine B.; Vogler, Thomas; Luftmann, Heinrich; Studer, Armido
Angewandte Chemie - International Edition, 2010 , vol. 49, # 17 p. 3073 - 3076
反应条件
in tetrahydrofuran Substitution;
参考文献
Piotrowski, David W.
Synlett, 1999 , # 7 p. 1091 - 1093
反应条件
n-butyllithium; diisopropylamine 1.) THF, hexane, -78 deg C, 15 min, 2.) a.) -78 deg C, 3 h, b.) 0 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Turner, James A.; Jacks, Wendy S.
Journal of Organic Chemistry, 1989 , vol. 54, # 17 p. 4229 - 4231
反应条件
1: (E)-4-methoxyacetophenone tosylhydrazone With Mes2Mg; lithium chloride in tetrahydrofuran T=40°C; Shapiro reaction; 3 h; 2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran T=40°C; 1 h; 3: With water-d2 in tetrahydrofuran
参考文献
Kerr, William J.; Morrison, Angus J.; Pazicky, Marek; Weber, Tina
Organic Letters, 2012 , vol. 14, # 9 p. 2250 - 2253
反应条件
boron trifluoride diethyl etherate in 1,4-dioxane T=20 - 100°C; Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 54, # 21 p. 2693 - 2695
