1-(4-环丙基苯基)乙酮合成路线 （共 17 条）
反应条件
K3PO4*7H2O; C45H53ClFeNO2PPd in water; toluene T=100°C; Suzuki coupling; 8 h; Inert atmosphere;
参考文献
Zhang, Min; Cui, Xiuling; Chen, Xiaopei; Wang, Lianhui; Li, Jingya; Wu, Yusheng; Hou, Lifen; Wu, Yangjie
Tetrahedron, 2012 , vol. 68, # 3 p. 900 - 905
反应条件
1: cyclopropyl bromide With tert.-butyl lithium in diethyl ether; pentane T=-78 - 20°C; 2: With indium(III) chloride in tetrahydrofuran; diethyl ether; pentane T=-78 - 20°C; 3: 4-acetylphenyl triflate With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran; diethyl ether; pentane 3 h; Heating; Further stages.;
参考文献
Perez, Ignacio; Sestelo, Jose Perez; Sarandeses, Luis A.
Organic Letters, 1999 , vol. 1, # 8 p. 1267 - 1269
反应条件
1: 2-cyclopropyl-[1,3,6,2]dioxazaborocane With hydrogenchloride; water; sodium chloride 2: para-bromoacetophenone With potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triphenylphosphine in MeTHF; water; toluene T=100°C; Suzuki Coupling; 3 h; Inert atmosphere; Product distribution / selectivity;
参考文献
MINAKEM; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S); UNIVERSITE PAUL SABATIER TOULOUSE III; BONIN-DUBARLE, Helene; GRAS, Emmanuel; DELBRAYELLE, Dominique; DEMONCHAUX, Patrice; DELACROIX, Thomas
Patent: WO2010/18211 A1, 2010 ;
Location in patent: Page/Page column 14-15 ;
反应条件
1: 2-cyclopropyl-[1,3,6,2]dioxazaborocane With hydrogenchloride; water; sodium chloride 2: para-chloroacetophenone With potassium phosphate; palladium diacetate; 1,3-bis(2,4,6-trimethylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene in MeTHF; toluene T=100°C; Suzuki Coupling; 48 h; Inert atmosphere; Product distribution / selectivity;
参考文献
MINAKEM; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S); UNIVERSITE PAUL SABATIER TOULOUSE III; BONIN-DUBARLE, Helene; GRAS, Emmanuel; DELBRAYELLE, Dominique; DEMONCHAUX, Patrice; DELACROIX, Thomas
Patent: WO2010/18211 A1, 2010 ;
Location in patent: Page/Page column 14; 16 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=90°C; 18 h;
参考文献
Gagnon, Alexandre; Duplessis, Martin; Alsabeh, Pamela; Barabe, Francis
Journal of Organic Chemistry, 2008 , vol. 73, # 9 p. 3604 - 3607
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=90°C; 18 h;
参考文献
Gagnon, Alexandre; Duplessis, Martin; Alsabeh, Pamela; Barabe, Francis
Journal of Organic Chemistry, 2008 , vol. 73, # 9 p. 3604 - 3607
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran 3 h; Heating;
参考文献
Perez; Sestelo; Sarandeses
Journal of the American Chemical Society, 2001 , vol. 123, # 18 p. 4155 - 4160
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran 3.5 h; Heating;
参考文献
Perez; Sestelo; Sarandeses
Journal of the American Chemical Society, 2001 , vol. 123, # 18 p. 4155 - 4160
反应条件
potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); all-cis-tetrakis[(diphenylphosphanyl)methyl]cyclopentane in xylene T=130°C; Suzuki cross-coupling; 20 h;
参考文献
Lemhadri, Mhamed; Doucet, Henri; Santelli, Maurice
Synthetic Communications, 2006 , vol. 36, # 1 p. 121 - 128
反应条件
aluminium trichloride in dichloromethane Ambient temperature;
参考文献
Byron, D. J.; Matharu, A. S.; Rees, M.; Wilson, R. C.
Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1995 , vol. 258, p. 229 - 238
