N'-(四氢吡喃-4-亚基)肼基羧酸叔丁酯合成路线 （共 6 条）
反应条件
1.1: borane-THF / 0.17 h / 20 °C 1.2: 0.75 h / |Reflux 2.1: triethylamine / ethanol / 3 h / |Reflux 3.1: water; dihydrogen peroxide; ammonia / ethanol / 19 h / 20 °C View Scheme
参考文献
CELON PHARMA S.A.; MOSZCZYŃSKI-PĘTKOWSKI, Rafał; BOJARSKI, Łukasz; STEFANIAK, Filip; WIECZOREK, Maciej; DUBIEL, Krzysztof; LAMPARSKA-PRZYBYSZ, Monika
Patent: WO2014/16789 A1, 2014 ;
反应条件
1.1: borane-THF / 0.17 h / 20 °C 1.2: 0.75 h / |Reflux 2.1: triethylamine / ethanol / 3 h / |Reflux View Scheme
反应条件
1: 100 percent / sodium cyanoborohydride; aq. acetic acid / 20 °C 2: 100 percent / CF3CO2H / CH2Cl2 / 20 °C View Scheme
参考文献
TYROGENEX, INC.; LIANG, Congxin
Patent: WO2011/41399 A2, 2011 ;
WO 2011/041399 A2
反应条件
1: sodium cyanoborohydride / acetic acid / 1.5 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 3: triethylamine / ethanol / 1 h / -78 - 0 °C View Scheme
参考文献
TYROGENEX, INC.; LIANG, Congxin
Patent: WO2011/41399 A2, 2011 ;
WO 2011/041399 A2
反应条件
sodium cyanoborohydride; acetic acid
T=20°C;
参考文献
TYROGENEX, INC.; LIANG, Congxin; LI, Zhigang
Patent: WO2010/56320 A2, 2010 ;
Location in patent: Page/Page column 54 ;
WO 2010/056320 A2
反应条件
1: in water
0.5 h;
2: With sodium cyanoborohydride in water
T=20°C; 2 h;
3: With sodium hydroxide; water
T=0°C;
参考文献
PFIZER INC.
Patent: WO2008/139293 A1, 2008 ;
Location in patent: Page/Page column 90; 46 ;
