1: 1,1-dimethylethyl[6-chloro-2-pyridinyl]carbamate With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane
T=-78°C;
2: 1-bromo-4-chloro-butane in tetrahydrofuran
Heating; Further stages.;
参考文献
Davies, Antony J.; Brands, Karel M. J.; Cowden, Cameron J.; Dolling, Ulf-H.; Lieberman, David R.
Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1721 - 1724
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in dichloromethane
Ambient temperature;
参考文献
Brown, Thomas J.; Chapman, Robert F.; Cook, David C.; Hart, Terance W.; McLay, Iain M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3613 - 3624
Crombie, Leslie; Haigh, David; Jones, Raymond C. F.; Mat-Zin, Ab. Rasid
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 17 p. 2047 - 2054
