2,3-二(十六烷氧基)丙基 2-(三甲基铵基)乙基磷酸酯合成路线 （共 10 条）
反应条件
1: NEt3 / diethyl ether / 22 h / 20 - 35 °C
2: NEt3; H2O / diethyl ether / 2 h
3: acetonitrile; CHCl3 / 14 h / 50 °C
View Scheme
参考文献
Browne, Judith E.; Freeman, Richard T.; Russell, Jeremy C.; Sammes, Peter G.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 5 p. 645 - 652
反应条件
1: H2 / PtO2 / ethyl acetate / 3000.2 Torr
2: CCl3CN, pyridine / 48 h / 50 °C
View Scheme
参考文献
Akita; Umezawa; Matsukura; Oishi
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 2 p. 318 - 324
反应条件
1: Et3N / toluene / 2 h / Ambient temperature
2: acetonitrile; propan-2-ol; H2O / 12 h / 60 °C
View Scheme
参考文献
Akita; Umezawa; Matsukura; Oishi
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 2 p. 318 - 324
反应条件
pyridine; trichloroacetonitrile
T=50°C; 48 h; Yield given;
参考文献
Akita; Umezawa; Matsukura; Oishi
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 2 p. 318 - 324
反应条件
in water; isopropyl alcohol; acetonitrile
T=60°C; 12 h; Yield given;
参考文献
Akita; Umezawa; Matsukura; Oishi
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 2 p. 318 - 324
反应条件
1: 54 percent / p-TsOH; MeOH / 16 h / 20 °C
2: NEt3 / diethyl ether / 22 h / 20 - 35 °C
3: NEt3; H2O / diethyl ether / 2 h
4: acetonitrile; CHCl3 / 14 h / 50 °C
View Scheme
参考文献
Browne, Judith E.; Freeman, Richard T.; Russell, Jeremy C.; Sammes, Peter G.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 5 p. 645 - 652
反应条件
1: NEt3; H2O / diethyl ether / 2 h
2: acetonitrile; CHCl3 / 14 h / 50 °C
View Scheme
参考文献
Browne, Judith E.; Freeman, Richard T.; Russell, Jeremy C.; Sammes, Peter G.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 5 p. 645 - 652
反应条件
1.1: NaH / dimethylformamide / 0.25 h / 20 °C
1.2: 68 percent / dimethylformamide / 16 h / 40 °C
2.1: 54 percent / p-TsOH; MeOH / 16 h / 20 °C
3.1: NEt3 / diethyl ether / 22 h / 20 - 35 °C
4.1: NEt3; H2O / diethyl ether / 2 h
5.1: acetonitrile; CHCl3 / 14 h / 50 °C
View Scheme
参考文献
Browne, Judith E.; Freeman, Richard T.; Russell, Jeremy C.; Sammes, Peter G.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 5 p. 645 - 652
反应条件
in chloroform; acetonitrile
T=50°C; Amination; 14 h;
参考文献
Browne, Judith E.; Freeman, Richard T.; Russell, Jeremy C.; Sammes, Peter G.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 5 p. 645 - 652
反应条件
(i) Et3N, CHCl3, (ii) aq. KCl, (iii) /BRN= 956566/; Multistep reaction;
参考文献
Eibl,H. et al.
Justus Liebigs Annalen der Chemie, 1967 , vol. 709, p. 226 - 230
