1: With trifluoromethyl amino ketone; potassium carbonate; N-methyl-2-(methylamino)ethylamine; copper(l) iodide in 1,4-dioxane T=75°C; 2: With methanol in 1,4-dioxane T=75°C; Further stages.;
1: piperidine With 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; palladium diacetate in toluene 0.0833333 h; 2: meta-bromobenzonitrile in toluene 0.0833333 h; 3: With caesium carbonate in toluene T=70°C; 48 h;
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US2006/25433 A1, 2006 ;
Location in patent: Page/Page column 131 ;
US 20060025433 A1
1: Bromure de phenyl magnesium With ihdium trichloride in tetrahydrofuran T=25°C; 2: meta-bromobenzonitrile With tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane in tetrahydrofuran; water 3.5 h; Heating; Further stages.;
