1: 4-hydroxybutanol With potassium tert-butylate in N,N-dimethyl-formamide
T=0 - 20°C; 1.5 h;
2: 3-(chloromethyl)pyridine monohydrochloride With potassium tert-butylate in N,N-dimethyl-formamide
T=-8 - -3°C;
3: With water
Product distribution / selectivity;
1: 4-hydroxybutanol With sodium t-butanolate in N,N-dimethyl-formamide
T=0 - 20°C; 1 h;
2: 3-(chloromethyl)pyridine monohydrochloride With sodium t-butanolate in N,N-dimethyl-formamide
T=-16 - 0°C;
3: With water in dichloromethane
Product distribution / selectivity;
