2,5-二甲氧基四氢呋喃合成路线 （共 286 条）
反应条件
sodium tetrahydroborate; sulfuric acid; water in tetrahydrofuran; methanol
T=10 - 20°C; 1.5 h; Yield given;
参考文献
Verardo, Giancarlo; Dolce, Anna; Toniutti, Nicoletta
Synthesis, 1999 , # 1 p. 74 - 79
反应条件
(i) aq. HCl, (ii) (H2N)2SO2; Multistep reaction;
参考文献
Dusemund
Archiv der Pharmazie, 1977 , vol. 310, # 7 p. 600 - 602
反应条件
montmorillonite K-10 in dichloromethane
T=80°C; 0.0666667 h; microwave irradiation;
参考文献
Abid, Mohammed; De Paolis, Omar; Toeroek, Bela
Synlett, 2008 , # 3 p. 410 - 412
参考文献
Elming; Clauson-Kaas
Acta Chemica Scandinavica (1947-1973), 1952 , vol. 6, p. 867,872
反应条件
in acetic acid
Heating;
参考文献
Martinez, Gregory R.; Walker, Keith A. M.; Hirschfeld, Donald R.; Maloney, Patrick J.; Yang, Diana S.; Rosenkranz, Roberto P.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 890 - 897
反应条件
1: D-2-aminopentanoic acid With thionyl chloride in methanol
2: 2,5-dimethoxy-tetrahydrofuran With sodium acetate in acetic acid
3: With potassium hydroxide in methanol
参考文献
Corvo, Marta C; Pereira, M.Manuela A
Tetrahedron Letters, 2002 , vol. 43, # 3 p. 455 - 458
反应条件
iron(III) chloride heptahydrate in water
T=60°C; Paal-Knorr pyrrole synthesis; 4 h;
参考文献
Azizi, Najmedin; Khajeh-Amiri, Alireza; Ghafuri, Hossein; Bolourtchian, Mohammad; Saidi, Mohammad Reza
Synlett, 2009 , # 14 p. 2245 - 2248
反应条件
acetic acid in 1,4-dioxane
Condensation;
参考文献
Pleus, Susanne; Schwientek, Marion
Synthetic Communications, 1997 , vol. 27, # 17 p. 2917 - 2930
反应条件
in 1,4-dioxane
1.) 4h, reflux, 2.) room temp., overnight;
参考文献
Jirkovsky, Ivo; Baudy, Reinhardt
Synthesis, 1981 , # 6 p. 481 - 483
反应条件
acetic acid
2 h; Reflux;
参考文献
GRUeNENTHAL GMBH; MERLA, Beatrix; OBERBOeRSCH, Stefan; REICH, Melanie; SCHUNK, Stefan; JOSTOCK, Ruth; HEES, Sabine; ENGELS, Michael; GERMANN, Tieno; BIJSTERVELD, Edward
Patent: WO2010/99938 A1, 2010 ;
Location in patent: Page/Page column 75-76 ;
