N-Boc-L-脯氨醇合成路线 （共 100 条）
反应条件
1: SO3; pyridine; DIPEA / dimethylsulfoxide; CH2Cl2 / 5 h / -5 °C 2: PPh3 / CH2Cl2 / 2 h / -5 - 0 °C 3: 83 percent / n-BuLi / tetrahydrofuran / 1.25 h / -78 °C View Scheme
参考文献
Cossy, Janine; Cases, Manuel; Pardo, Domingo Gomez
Bulletin de la Societe Chimique de France, 1997 , vol. 134, # 2 p. 141 - 144
反应条件
1: DEAD, PPh3 2: HCO2H View Scheme
参考文献
Lin, Nan-Horng; Gunn, David E.; Li, Yihong; He, Yun; Bai, Hao; Ryther, Keith B.; Kuntzweiler, Theresa; Donnelly-Roberts, Diana L.; Anderson, David J.; Campbell, Jeffrey E.; Sullivan, James P.; Arneric, Stephen P.; Holladay, Mark W.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 3 p. 249 - 254
反应条件
hydrogen azide; di-isopropyl azodicarboxylate; triphenylphosphine in benzene T=0 - 20°C; Mitsunobu Displacement; 0.833333 h;
参考文献
Vega-Penaloza, Alberto; Sanchez-Antonio, Omar; Escudero-Casao, Margarita; Tasnadi, Gabor; Fueloep, Ferenc; Juaristi, Eusebio
Synthesis (Germany), 2013 , vol. 45, # 17 art. no. SS-2013-M0321-OP, p. 2458 - 2468
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran
参考文献
Patel, Dinesh; Jacobs, Jeffrey W.; Jain, Rakesh; Ni, Zhi-Jie; Yuan, Zhengyu
Patent: US2002/115863 A1, 2002 ;
参考文献
THE UNIVERSITY OF EDINBURGH
Patent: WO2009/112845 A1, 2009 ;
Location in patent: Page/Page column 140 ;
WO 2009/112845 A1
反应条件
1.1: 70 percent / pyridine / CH2Cl2 / 16 h / 20 °C 2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 2.2: 78 percent / tetrahydrofuran / 12 h / Heating View Scheme
参考文献
Lee; Long; Murray; Adams; Nuttall; Nadeau; Kikly; Winkler; Sung; Ryan; Levy; Keller; DeWolf Jr.
Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 2015 - 2026
参考文献
Abbott Laboratories
Patent: US5472958 A1, 1995 ;
US 5472958 A
反应条件
1.1: 70 percent / pyridine / CH2Cl2 / 16 h / 20 °C 2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 2.2: 78 percent / tetrahydrofuran / 12 h / Heating 3.1: TFA / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Lee; Long; Murray; Adams; Nuttall; Nadeau; Kikly; Winkler; Sung; Ryan; Levy; Keller; DeWolf Jr.
Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 2015 - 2026
反应条件
1.1: 100 percent / pyridine / CH2Cl2 / 20 °C 2.1: NaH / tetrahydrofuran / 0.67 h / 0 - 20 °C 2.2: 61 percent / tetrahydrofuran / 24 h / Heating 3.1: CF3CO2H / CH2Cl2 / 0.25 h / 0 °C View Scheme
参考文献
Abreo, Melwyn A.; Lin, Nan-Horng; Garvey, David S.; Gunn, David E.; Hettinger, Ann-Marie; Wasicak, James T.; Pavlik, Patricia A.; Martin, Yvonne C.; Donnelly-Roberts, Diana L.; Anderson, David J.; Sullivan, James P.; Williams, Michael; Arneric, Stephen P.; Holladay, Mark W.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 817 - 825
反应条件
1: 96 percent / Et3N / CH2Cl2 / 12 h / 20 °C 2: 54 percent / LiEt3BH / tetrahydrofuran / Heating View Scheme
参考文献
Zhao, Dalian; Kuethe, Jeffrey T.; Journet, Michel; Peng, Zhihui; Humphrey, Guy R.
Journal of Organic Chemistry, 2006 , vol. 71, # 11 p. 4336 - 4338
