1-(3,6-二羟基-2,4-二甲氧基苯基)-乙酮合成路线 （共 35 条）
反应条件
aluminium trichloride; nitrobenzene
参考文献
Chapman; Perkin; Robinson
Journal of the Chemical Society, 1927 , p. 3020
反应条件
(i) BF3, (ii) aq. HCl, EtOH; Multistep reaction;
参考文献
Stout,M.S. et al.
Journal of Pharmaceutical Sciences, 1964 , vol. 53, p. 192 - 195
参考文献
Iinuma, Munekazu; Matsuura, Shin; Tanaka, Toshiyuki
Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 4 p. 1472 - 1476
参考文献
Oliverio; Bargellini
Gazzetta Chimica Italiana, 1948 , vol. 78, p. 386,394
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Mauthner
Journal fuer Praktische Chemie (Leipzig), 1936 , vol. <2> 147, p. 287,289
反应条件
1: i-Pr2NEt / CH2Cl2
2: pyridine / 50 - 60 °C
3: KOH, pyridine / 80 °C
4: 88 percent / conc. H2SO4, AcOH / 60 °C
View Scheme
参考文献
Horie; Kobayashi; Kawamura; Yoshida; Tominaga; Yamashita
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 7 p. 2033 - 2041
反应条件
anhydrous sodium benzoate
T=180°C; Unter vermindertem Druck und anschliessend Erwaermen mit wss.-aethanol. Kalilauge;
参考文献
Sastri; Seshadri
Proceedings - Indian Academy of Sciences, Section A, 1946 , # 23 p. 273,276
反应条件
sodium 3,4-dimethoxybenzoate
T=180°C; unter vermindertem Druck; Erhitzen des Reaktionsprodukts mit wss. Jodwasserstoffsaeure und Acetanhydrid;
参考文献
Murti; Seshadri
Proceedings - Indian Academy of Sciences, Section A, 1948 , # 27 p. 217,220
反应条件
1: 88 percent / potassium carbonate / dimethylformamide / 0.17 h / 160 °C
2: 87 percent / KOH / ethanol / 50 °C
3: 1.)Tl(NO3)3*3H2O, 2.)Na2SO3, 5percent HCl / 1.) CHCl3, 30 deg C, 24 h 2.) 0 deg C
4: H2 / 10percent Pd/C / methanol; ethyl acetate / Ambient temperature
5: 68 percent / aq 10percent HCl / methanol / Heating
6: 96 percent / pyridine / Heating
7: 1.) AlCl3 2.)aq HCl / 1.) MeCN, 70 deg C, 2.) MeCN,50-60 deg C, 30 min
View Scheme
参考文献
Horie, Tokunaru; Sasagawa, Masahiro; Torii, Furaihito; Kawamura, Yasuhiko; Yamashita, Kazuyo
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 3 p. 486 - 491
反应条件
1: sodium-veratrate / 180 °C / unter vermindertem Druck; Erhitzen des Reaktionsprodukts mit wss. Jodwasserstoffsaeure und Acetanhydrid
2: acetone; potassium carbonate
View Scheme
参考文献
Murti; Seshadri
Proceedings - Indian Academy of Sciences, Section A, 1948 , # 27 p. 217,220
反应条件
potassium hydroxide
Ansaeuern des Reaktionsgemisches mit wss. Salzsaeure;
参考文献
Zemplen et al.
Acta Chimica Academiae Scientiarum Hungaricae, 1958 , vol. 14, p. 471,473
